Elevated A1C is associated with impaired early-phase insulin secretion rather than insulin resistance in Koreans at high risk for developing diabetes.

Endocrine
Tae Nyun KimSei Hyun Baik

Abstract

The purpose of this study is to examine the association of A1C with beta-cell dysfunction, insulin resistance, and cardiovascular risk factors in Koreans with the relatively high risk for the future development of diabetes. This cross-sectional study recruited subjects from the pre-diabetic cohort of the Korea National Diabetes Program. Among study subjects (n = 616) aged 21-77 years with a history of hyperglycemia (fasting plasma glucose (FPG) ≥ 5.5 mmol/mL), analyses were conducted on 504 participants (296 women, 208 men) except for subjects with FPG ≥ 7.0 mmol/L or 120-min post-challenge plasma glucose ≥ 11.1 mmol/L or A1C ≥ 6.5 %. For insulin sensitivity and β-cell function classified by the categories of A1C levels, ∆Ins(30-0)/∆Glu(30-0) was lower in the highest quartile group than other groups. Although there was no significant difference in HOMA-IR according to the A1C categories, even lowest A1C group (≤ 5.3 %) already included many subjects with abnormal glucose tolerance. A1C showed a significant association with hsCRP, number of metabolic syndrome (MetS) components and ∆Ins(30-0)/∆Glu(30-0) after adjusting for age, gender, BMI, and medications whereas HOMA-IR was insignificantly associated with A1C. Stepwise regressi...Continue Reading

References

Dec 24, 1997·Diabetes Care·C S ShinB G Yang
Jul 24, 2001·JAMA : the Journal of the American Medical Association·A D PradhanP M Ridker
Jun 28, 2002·Diabetes·Christine C JensenUNKNOWN American Diabetes Association GENNID Study Group
Aug 21, 2002·Annals of Internal Medicine·R Graham BarrDaniel E Singer
Sep 28, 2002·Diabetes·Robert L HansonWilliam C Knowler
Dec 28, 2002·Diabetes Care·UNKNOWN Expert Committee on the Diagnosis and Classification of Diabetes Mellitus
Feb 10, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Scott M GrundyUNKNOWN American Heart Association
Feb 28, 2004·Diabetes·Frank B HuJoAnn E Manson
May 27, 2004·Diabetes Care·Tara M WallaceDavid R Matthews
Dec 22, 2004·Journal of General Internal Medicine·David EdelmanEugene Z Oddone
Feb 4, 2005·Metabolism: Clinical and Experimental·Eun Seok KangHyun Chul Lee
Apr 20, 2005·Lancet·Robert H EckelPaul Z Zimmet
Apr 22, 2006·American Journal of Preventive Medicine·Linda S GeissMichael M Engelgau
Mar 1, 2007·Diabetes·Abbas DehghanJacqueline C M Witteman
Mar 27, 2007·Translational Research : the Journal of Laboratory and Clinical Medicine·Tamae ShimazakiKiyoshi Kubota
Aug 7, 2007·The American Journal of Medicine·Aruna D PradhanPaul M Ridker
Jul 2, 2008·Diabetes Care·Earl S FordNaveed Sattar
May 28, 2009·JAMA : the Journal of the American Medical Association·Juliana C N ChanFrank B Hu
Jun 9, 2009·Diabetes Care·UNKNOWN International Expert Committee
Jul 14, 2009·Diabetes Care·Cris A SlentzWilliam E Kraus

❮ Previous
Next ❯

Citations

Nov 18, 2014·Diabetes/metabolism Research and Reviews·Michael Bergman
May 3, 2016·Journal of Pediatric Nursing·Jennifer McGuire HittPatricia Cowan
Oct 30, 2018·The Cochrane Database of Systematic Reviews·Bernd RichterYemisi Takwoingi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.