Elevated absolute monocyte count predicts unfavorable outcomes in patients with angioimmunoblastic T-cell lymphoma

Leukemia Research
Yu-Qiong YangWei Xu

Abstract

This study was aimed at investigating the prognostic significance of the absolute monocyte count (AMC) in peripheral blood in patients with newly diagnosed angioimmunoblastic T cell lymphoma (AITL). AMC was performed in 73 therapy-naive patients with AITL in 2 institutions during 2008-2015, and higher AMC was observed in those with extranodal sites >1, bone marrow involvement, high lactate dehydrogenase level, the EBV infection, no response to treatment and high IPI, PIT, PIAI score group. The best AMC cut-off level at diagnosis was 0.8×10(9)/L and the 3-year overall survival (OS) was 64% for patients with low AMC group (≤0.8×10(9)/L) compared to 10% in high AMC group (>0.8×10(9)/L) (P<0.001). Multivariate analysis showed that elevated AMC remained an adverse prognostic parameter. Our results suggest that AMC is an independent prognostic parameter for OS in patients with AITL, and AMC >0.8×10(9)/L can routinely be used to identify high-risk patients with unfavorable survival.

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Citations

Sep 7, 2016·Vaccines·Saskia J A M SantegoetsSjoerd H van der Burg
Aug 29, 2018·Scientific Reports·Yufeng ShangMingzhi Zhang
Jun 28, 2019·Annals of Hematology·Luís Alberto de Pádua Covas LageJuliana Pereira

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