Elevated alanine aminotransferase (ALT) in the deceased donor: impact on early post-transplant liver allograft function

Liver International : Official Journal of the International Association for the Study of the Liver
Richard S MangusA Joseph Tector

Abstract

Serum alanine aminotransferase (ALT) levels are frequently elevated with liver injury and such elevations are common in deceased organ donors. The impact of this injury on early liver allograft function has not been well described. This study analyses the immediate function and 1-year graft and patient survival for liver allografts stratified by peak serum ALT levels in the deceased donor. The on-site organ procurement records for 1348 consecutive deceased liver donors were reviewed (2001–2011). Serum ALT was categorized into three study groups: normal/mild elevation, 0–499 μ/L; moderate elevation, 500–999 μ/L (>10× upper limit of normal) and severe elevation, ≥1000 μ/L (>20× upper limit of normal). Outcomes included early graft function and graft loss, and 1-year graft and patient survival. Distribution of subjects included: normal/mild, 1259 (93%); moderate, 34 (3%) and severe, 55 (4%). Risk of 30-day graft loss for the three study groups was: 72 (6%), 3 (9%) and 3 (6%) (P = 0.74). Graft and patient survival at 1 year for the three groups was: normal/mild, 1031 (87%), 1048 (88%); moderate, 31 (91%), 31 (91%) and severe, 43 (88%), 44 (90%) (P = 0.71, 0.79). Cox proportional hazards modelling of survival while controlling for d...Continue Reading

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Citations

Oct 30, 2016·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Yan-Hong LiZhao-Xiang Bian
Aug 19, 2018·Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation·Paulo N MartinsAdel Bozorgzadeh
Jan 21, 2015·Transplant International : Official Journal of the European Society for Organ Transplantation·A Claire den DulkBart van Hoek
Aug 20, 2019·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Melissa G KaltenbachDavid S Goldberg
Oct 26, 2018·World Journal of Gastroenterology : WJG·Ya-Fei ZhangYi-Ming Li
Jun 30, 2019·Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation·Oleg SlivcaTimothy L Pruett
May 19, 2020·International Journal of Surgery·Nicolas GoldaracenaKarim J Halazun
Feb 20, 2021·Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation·Ioannis A ZiogasMartin I Montenovo
Mar 25, 2021·Transplantation·Paulo N MartinsUNKNOWN ILTS Special Interest Group “DCD, Preservation and Machine Perfusion”
Apr 16, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Yujiao YangJiao Guo
Jun 9, 2018·Transplantation Proceedings·R S MangusC A Kubal

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