PMID: 9193775Oct 1, 1996Paper

Elevated aminotransferase activity as an indication of muscular dystrophy: case reports and review of the literature

Canadian Journal of Gastroenterology = Journal Canadien De Gastroenterologie
S ZamoraR B Scott

Abstract

Five male children are reported in whom incidental recognition of elevated serum alanine aminotransferase (ALT) activity initiated investigation to identity the cause of suspected hepatocellular injury. All five were later diagnosed with X chromosome-linked muscular dystrophy. The serum level of ALT, generally considered to be specific for hepatocellular injury, was increased two to 25 times above normal in all the reported cases. Paradoxically, the increase in ALT activity was greater than that of serum aspartate aminotransferase (three to 16 times normal), an enzyme whose elevation is generally recognized as being less specific and indicative of muscle, cardiac, kidney, pancreatic, red blood cell or hepatic injury. At presentation to the gastrointestinal service, one case, age 2.5 months, had no symptoms or signs of neuromuscular dysfunction, while the other four had previously unrecognized hypertrophy of the calves, proximal limb weakness, positive Gower's sign or delayed gross motor skills. All five patients had marked elevation of serum creatine kinase activity and histopathologically confirmed muscular dystrophy. The practical clinical implication of this report is that children with elevated serum ALT, in the absence of ...Continue Reading

Citations

Jul 2, 2005·Journal of Pediatric Gastroenterology and Nutrition·Rohit KohliPeter F Whitington
May 27, 2010·Journal of Paediatrics and Child Health·Claudio VeropalumboPietro Vajro
Sep 8, 2017·Metabolites·Laura K SchnackenbergRichard D Beger
Jun 28, 2001·American Journal of Hematology·D N KoronesJ Palis
Oct 5, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P MohanN L Luban
Nov 19, 2002·Current Opinion in Pediatrics·David T Miller, Laura R Ment
Jun 20, 2012·Journal of Pediatric Gastroenterology and Nutrition·Daniele SerrantiMassimo Resti
Dec 11, 2014·Journal of Pediatric Gastroenterology and Nutrition·Alexandra C Russell, Lynette A Gillis
Jun 11, 2020·American Journal of Physical Medicine & Rehabilitation·Maricela Rodríguez-CruzMariela Bernabe-García
May 16, 2009·Clinics in Liver Disease·Michael Krier, Aijaz Ahmed

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