PMID: 15222695Jun 30, 2004Paper

Elevated aminotransferases during treatment with interferon-beta for multiple sclerosis: actions and outcomes

Multiple Sclerosis : Clinical and Laboratory Research
Helen Tremlett, Joel Oger

Abstract

The authors report further analysis of a six-year retrospective chart review of multiple sclerosis (MS) patients prescribed interferon-beta (IFNB) in British Columbia, Canada. Actions and outcomes taken when 284/835 (34%) of the patients developed de novo elevated aminotransferases are presented; 239/284 (84%) of patients were continued on treatment despite these elevations; 216/246 (88%) of patients reaching grade 1 toxicity (greater than the upper limit of normal) continued IFNB treatment; of these, 167/216 (77%) returned to within normal limits. Of the 22/29 (76%) reaching grade 2 toxicity (> 2.5 times the upper limit of normal) and continuing treatment, 14/22 (64%) returned to within the normal range. One of the nine patients reaching grade 3 toxicity ( > 5 times the upper limit of normal) was allowed continue treatment and their aminotransferase levels returned to within normal limits. However, one patient reaching grade 3 toxicity went on to develop liver failure (previously reported).

References

Oct 24, 2001·Neurology·L DurelliUNKNOWN Betaferon Safety Trial (BEST) Study Group

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Citations

Mar 15, 2006·Expert Review of Neurotherapeutics·Dean M Wingerchuk
Aug 20, 2014·Expert Opinion on Drug Safety·Kaarina KowalecHelen Tremlett
Jan 3, 2008·Transplant International : Official Journal of the European Society for Organ Transplantation·Giada PietrosiBruno Gridelli
Feb 5, 2013·Digestive Diseases and Sciences·Robert J FontanaMarwan Ghabril
Apr 25, 2012·Cellular and Molecular Life Sciences : CMLS·Kristina LudigsGreta Guarda
May 26, 2021·La Presse médicale·Ilaria CallegariEdoardo Galli

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