Elevated amniotic fluid leptin levels in pregnant women who are destined to develop preeclampsia

Acta Obstetricia Et Gynecologica Scandinavica
Te-Fu ChanShyng-Shiou F Yuan

Abstract

To analyze whether leptin levels of the amniotic fluid elevate during early pregnancy in women destined to develop preeclampsia and to evaluate the relationship between amniotic fluid leptin levels and gestational age, maternal body mass index, and fetal sex. Leptin levels of the amniotic fluid were compared in two groups of women, preeclamptic (n = 20) and normotensive pregnant (n = 40), matched for fetal sex, maternal body mass index at sampling, gravidity and fetal gestational age at sampling. Furthermore, amniotic leptin levels in 400 normotensive pregnant women were analyzed for their correlation with gestational age, maternal body mass index, and fetal sex. Median leptin concentrations were significantly higher (p < 0.001) in the women with preeclampsia (7.3+/-0.7 ng/ml) than in the normotensive pregnant women (4.1 +/- 0.3 ng/ml), independent of fetal sex. The leptin levels in the amniotic fluid decreased with advanced gestational age (r = 0.24, p < 0.001). Amniotic fluid leptin levels in the pregnant women carrying a female fetus (5.6+/-0.3ng/ml) were significantly higher than those carrying a male fetus (4.7+/-0.2 ng/ml) (p = 0.004). Higher amniotic fluid leptin levels were observed in the preeclamptic pregnant women, a...Continue Reading

Citations

Jul 12, 2012·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·A DemirS Guclu
Sep 25, 2014·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Alan ColemanFoong-Yen Lim
Sep 16, 2015·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Arrigo FruscalzoLorenza Driul
Feb 23, 2010·Medical Hypotheses·Andrea L Tranquilli, Beatrice Landi
Aug 11, 2007·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Sorina Grisaru-GranovskyDeborah Elstein
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Jan 1, 2012·Acta Medica (Hradec Králové)·Hugo Mendieta ZerónEdgar Denova Gutiérrez
Nov 14, 2006·Current Opinion in Obstetrics & Gynecology

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