Elevated angiogenin levels in the peritoneal fluid of women with endometriosis correlate with the extent of the disorder

Fertility and Sterility
Nobuhiro SuzumoriKaoru Suzumori

Abstract

To assess the release of angiogenin into peritoneal fluid in women with and without endometriosis by measuring its concentration with reference to disease stage, presence of red lesions, and phase of the menstrual cycle. Retrospective study. Nagoya City University Hospital. Sixty-four women with endometriosis (n = 38) and cystadenomas (n = 26) for whom surgery was scheduled in the proliferative or secretory phase of the menstrual cycle. Peritoneal fluid samples were obtained at laparotomy or laparoscopy. Angiogenin concentrations in the peritoneal fluid, as measured by ELISA. Angiogenin concentration in the peritoneal fluid was markedly elevated in the endometriosis patients (median 515 ng/mL, interquartile range 151-1763 ng/mL) compared with the cystadenoma (control) patients (195 ng/mL, 98-324 ng/mL), with values correlating with the extent of the disease. No significant differences between the proliferative phase and the secretory phase were observed in either the controls or the endometriosis patients. The inflammation associated with endometriosis, through increasing levels of peritoneal fluid angiogenin, might promote angiogenesis for progression of the disease and correlate with the extent of the disorder.

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Citations

Apr 5, 2013·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Ali YalçındağF Nilüfer Yalçındağ
Mar 4, 2014·Reproductive Biomedicine Online·Niv PencovichOfer Fainaru
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Dec 26, 2015·Acta Biochimica Et Biophysica Sinica·Jinghao Sheng, Zhengping Xu
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Apr 16, 2016·Cytokine & Growth Factor Reviews·Ganji Purnachandra NagarajuSubasini Pattnaik
Jun 15, 2013·Obstetrics and Gynecology International·Ana Luiza L RochaRobert N Taylor
Jul 24, 2012·Fertility and Sterility·Richard O Burney, Linda C Giudice
Oct 29, 2008·Journal of Korean Medical Science·Sung Hoon KimByung Moon Kang
Oct 18, 2018·Biology of Reproduction·Nikola SekulovskiKanako Hayashi
Sep 18, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ofer FainaruJudah Folkman
Jul 8, 2008·Acta Biochimica Et Biophysica Sinica·Xiangwei Gao, Zhengping Xu
Aug 2, 2005·Human Reproduction·Yuri TakemuraYuji Taketani
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Mar 10, 2007·Human Reproduction Update·Matthias W Laschke, Michael D Menger
Jan 18, 2020·Biology of Reproduction·Nikola SekulovskiKanako Hayashi
May 26, 2021·Obstetrical & Gynecological Survey·Nikolaos ThanatsisApostolos Kaponis

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