Elevated Arterial-Central Venous Carbon Dioxide Partial Pressure Difference Indicates Poor Prognosis in the Early Postoperative Period of Open Heart Surgery in Infants with Congenital Heart Disease.

Pediatric Cardiology
Xiaolei GongZhuoming Xu

Abstract

Elevated arterial-central venous carbon dioxide partial pressure difference (AVCO2) may be an important marker to predict tissue and organ hypoperfusion in adults. We analyzed the hemodynamic data of infants with congenital heart disease who underwent corrective repair with cardiopulmonary bypass (CPB) to identify whether AVCO2 has clinical significance in early postoperative tissue hypoperfusion, occurrence of complications, and clinical outcomes. Infants with clinical conditions of hypoperfusion, without volume responsiveness and with ineffective initial treatment, within 3 h of cardiac surgery were enrolled in this study. A pulse contour cardiac output catheter was used to monitor the cardiac index (CI). Eight measurements of arterial blood gas and central venous blood gas were taken within 42 h after surgery. Clinical data of all patients were recorded. A total of 69 children were enrolled in this study. Arteriovenous oxygen difference, AVCO2, lactic acid level, and vasoactive inotropic score in the hypoperfusion group (oxygen supply/oxygen consumption ratio [DO2/VO2] of ≤ 2) were significantly higher than those in the non-hypoperfusion group (DO2/VO2 > 2), while the CI in the hypoperfusion group was significantly lower tha...Continue Reading

References

Oct 1, 1991·Critical Care Medicine·C K MahutteD H Wong
May 1, 1991·Critical Care Medicine·S M Cain, S E Curtis
Apr 2, 2005·Intensive Care Medicine·Joseph CuschieriH Mathilda Horst
Aug 23, 2005·Asian Cardiovascular & Thoracic Annals·Yoshiyuki Takami, Hiroshi Masumoto
Apr 6, 2013·Intensive Care Medicine·Paul A van BeestE Christiaan Boerma
Nov 1, 2013·The New England Journal of Medicine·Jean-Louis Vincent, Daniel De Backer
Dec 18, 2013·Critical Care : the Official Journal of the Critical Care Forum·Gustavo A Ospina-TascónGlenn Hernández
May 15, 2015·Critical Care : the Official Journal of the Critical Care Forum·Emmanuel RobinBenoit Vallet
Aug 11, 2016·Clinical Cardiology·Hoong Sern Lim
Jan 26, 2017·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Leslie A RhodesJeffrey A Alten
May 2, 2017·Journal of Cardiothoracic and Vascular Anesthesia·Pierre-Grégoire GuinotHervé Dupont
Jun 18, 2017·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Takaaki AkamatsuMuneyuki Takeuchi
Mar 22, 2018·Current Opinion in Critical Care·Thomas W L ScheerenJean-Louis Teboul

❮ Previous
Next ❯

Related Concepts

Related Feeds

Biomarkers for Cardiovascular Risk Assessment

Sensitive and accurate biomarkers used in cardiovascular risk prediction can potentially be used to manage the risk of cardiovascular disease. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here.