Abstract
To determine whether elevated B-type natriuretic peptide (BNP) predicts left ventricular (LV) contractile dysfunction on exercise stress echocardiography in patients with severe mitral regurgitation (MR). Thirty three patients with moderate-to-severe or severe MR, a LV ejection fraction > or =60% and New York Heart Association Class I or II symptoms, and 12 controls underwent resting and exercise stress echocardiography. In 20 MR patients, BNP was within the normal range (mean +/- SD, 7.7 +/- 2.7 pmol/L), and in 13 MR patients, BNP was >12 pmol/L (19.6 +/- 7.6 pmol/L). LV end-systolic volume index after exercise was lower in controls than patients with MR (P < 0.0001), but similar in MR patients with normal and elevated BNP, respectively (controls 8.5 +/- 3.9, MR 20 +/- 7 vs. 20 +/- 9 cm(2)/m(2), P > 0.05). However, pulmonary artery systolic pressure (PAP) after exercise was higher in MR with high BNP (70 +/- 20 vs. 48 +/- 11 mmHg, <0.0001) and controls (38+/-11 mmHg). A two-fold increase in plasma BNP was associated with an average increase in resting PAP of 7.6 (95% CI 2.9, 12.2) mmHg, an increase in post-exercise PAP of 14.4 (95% CI 9.0, 19.9) mmHg and increase in left atrial area index of 2.1 (95% CI 0.5, 3.8) cm(2)/m(2). H...Continue Reading
Citations
Nov 30, 2010·European Heart Journal·Roland Hetzer, Michael Dandel
Oct 7, 2009·Future Cardiology·Andrew C Y To, Ralph Ah Stewart
Feb 18, 2010·Journal of Endocrinological Investigation·M FeolaG Visconti
Feb 25, 2009·Current Cardiology Reports·Jutta Bergler-Klein
May 24, 2011·Heart, Lung & Circulation·Vishal SharmaAndrew J Kerr
Dec 15, 2015·The American Journal of Cardiology·Amgad MentiasMilind Y Desai
Jul 12, 2012·European Journal of Heart Failure·Julien MagnePatrizio Lancellotti
Nov 6, 2010·European Journal of Heart Failure·Ursula KlaarHelmut Baumgartner
Aug 26, 2014·The Canadian Journal of Cardiology·Jutta Bergler-KleinGerald Maurer
Aug 13, 2015·Disease Markers·Abhishek SharmaChirag Aggarwal
May 8, 2010·Journal of the American College of Cardiology·Christopher D SteadmanGerry P McCann
Sep 12, 2009·Journal of the American College of Cardiology·Rodolfo PizarroArturo M Cagide
Sep 12, 2009·Journal of the American College of Cardiology·Peter A McCullough, George S Hanzel
Jun 14, 2016·Heart Views : the Official Journal of the Gulf Heart Association·Eman M Abdel FattahGhada M Ezzat
Apr 11, 2017·The American Journal of Cardiology·Ji-Won HwangSeung Woo Park
Mar 19, 2015·Circulation. Heart Failure·Vishal ParikhFlorian Rader
Jun 28, 2016·Circulation. Cardiovascular Imaging·Alaa AlashiMilind Y Desai
Nov 9, 2012·Circulation·K M John ChanUNKNOWN RIME Investigators
Aug 1, 2008·Expert Review of Cardiovascular Therapy·Luis M MouraNalini Rajamannan
Mar 10, 2017·Heart·Michael M JohlRobert J Siegel
Jul 23, 2013·Physiological Research·D R WoodsC Boos
Sep 26, 2020·Journal of the American College of Cardiology·Daniel E FormanUNKNOWN Geriatric Cardiology Section Leadership Council
Oct 19, 2020·Cardiology·Gabby Elbaz-GreenerOffer Amir