Elevated B-type natriuretic peptide levels in patients with nonischemic cardiomyopathy predict occurrence of arrhythmic events

Clinical Research in Cardiology : Official Journal of the German Cardiac Society
Tobias SimonAlexander Bauer

Abstract

Patients with nonischemic cardiomyopathy (DCM) are at high risk for sudden cardiac death (SCD). However, the predictive value of prophylactic implantation of implantable cardioverter defibrillators (ICD) in this patient cohort is yet unclear. Whether NT pro BNP levels and/or reproducible non sustained ventricular tachycardias (NSVTs) are predictive for SCD was prospectively tested in 30 patients with DCM and LVEF </= 40%. All patients received Holter-recordings (HR) on three consecutive days and baseline NT-pro BNP levels were determined. Patients were followed for occurrence of ventricular tachyarrhythmias or unexplained syncope. A great degree of variability was found regarding the occurrence of NSVTs (10% had NSVTs in two consecutive HR, 10% in three consecutive HR, 30% in one HR and 50% had no NSVTs). Patients with NSVTs in more than one HR had significantly higher NT-pro BNP levels (first quartile: 715 pg/ml, median 2,176 pg/ml, third quartile 5,755 pg/ml vs. first quartile 273 pg/ml, median 566 pg/ml, third quartile 1,350 pg/ml, P = 0.0388). During a mean follow-up of 21.6 +/- 1.2 months patients with an arrhythmic event had significantly higher NT-pro BNP levels than patients without event (first quartile: 1,002 pg/ml, m...Continue Reading

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Citations

May 31, 2008·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Christian StormDietrich Hasper
Nov 1, 2008·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Konstantinos P LetsasFotios Kardaras
Aug 13, 2008·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Joerg HonoldIoakim Spyridopoulos
Aug 19, 2009·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Tiina Marjatta SaloK E Juhani Airaksinen
Sep 18, 2010·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Ch SinningS Blankenberg
Oct 19, 2010·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Johanna A MiettinenHeikki V Huikuri
Nov 26, 2010·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Jan Giso PeterIngo Fietze
Apr 9, 2011·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·R PfeiferA Voss
May 4, 2011·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Amir M NiaFikret Er
Jul 23, 2011·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Jennifer FrankeChristian Zugck
Jan 5, 2013·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·David M LeistnerAndreas M Zeiher
Oct 6, 2009·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Emmanuel M KanoupakisPanos E Vardas
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Feb 26, 2019·Circulation·Jeanne du Fay de LavallazChristian Mueller

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