Elevated baseline plasma IL-8 levels are an independent predictor of long-term all-cause mortality in patients with acute coronary syndrome

Atherosclerosis
Erdal CavusogluCalvin Eng

Abstract

To investigate the long-term prognostic significance of baseline plasma IL-8 levels in a group of well-characterized male patients presenting with acute coronary syndrome. IL-8 is a cytokine that has been implicated in the pathogenesis of atherosclerosis and acute coronary syndrome. Elevated plasma levels have been reported in patients with acute coronary syndrome. Baseline plasma IL-8 levels were measured in 180 male patients with acute coronary syndrome who were referred for coronary angiography and followed prospectively for the development of all-cause mortality for 5 years. In a multivariate model that included a wide variety of baseline clinical, laboratory and angiographic parameters in the selection process, baseline plasma IL-8 levels (analyzed as a continuous variable) emerged as a significant predictor of all-cause mortality at 5 years (HR, 1.43; 95% CI, 1.08-1.88; p = 0.0123). Furthermore, in 3 additional multivariate models that also included in the selection process a number of contemporary biomarkers with established prognostic efficacy in ACS (i.e., NT-proBNP, hs-CRP, hemoglobin and RDW), IL-8 remained an independent predictor of all-cause mortality at 5 years. Elevated baseline plasma levels of IL-8 are associa...Continue Reading

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Citations

Sep 29, 2011·European Journal of Cell Biology·Ute RaffetsederPeter R Mertens
Mar 8, 2011·Clinica Chimica Acta; International Journal of Clinical Chemistry·Xue QinLiying Yuan
Apr 20, 2018·International Journal of Rheumatic Diseases·Maryam SanjadiSaeed Aslani
May 23, 2019·Proceedings of the National Academy of Sciences of the United States of America·Anthony S ZannasElisabeth B Binder
Jun 5, 2018·Heart Failure Reviews·Monika BartekovaNaranjan S Dhalla
Apr 14, 2020·Current Pharmaceutical Design·Konstantinos MourouzisDimitris Tousoulis
May 27, 2020·Journal of Cardiothoracic and Vascular Anesthesia·Lulu MaYuguang Huang

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