Elevated blood levels of Dickkopf-1 are associated with acute infections

Immunity, Inflammation and Disease
Melody MazonMadeleine Carreau

Abstract

Dickkopf-1 (DKK1) is a soluble protein and antagonist of the Wnt/β-catenin signaling pathway. DKK1 is found elevated in serum from patients affected with various types of cancers and in some instances, it is considered a diagnostic and prognostic biomarker. Elevated serum levels of DKK1 have also been detected in animal models of chronic inflammatory diseases. Previous work from our laboratory has demonstrated upregulation of DKK1 in cells and mouse models of the bone marrow failure (BMF) and cancer-prone disease Fanconi anemia (FA). The present study aimed to investigate whether DKK1 blood levels in patients are associated with FA or inflammatory responses to acute infections. Plasma samples were collected from 58 children admitted to the Centre Mère-Enfant Soleil du Centre Hospitalier de Québec-Université Laval with signs of acute infections. Blood plasma specimens were also collected from healthy blood donors at the Héma-Québec blood donor clinic. Plasmas from patients diagnosed with FA were also included in the study. DKK1 levels in blood plasmas were assessed by standard ELISA. Patients with acute infections showed dramatically high levels of DKK1 (6072 ± 518 pg/ml) in their blood compared to healthy blood donors (1726 ± 9...Continue Reading

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Citations

Jul 2, 2020·Cancer Management and Research·Jie LiWentao Yue
Jun 22, 2019·Differentiation; Research in Biological Diversity·Wook-Jin Chae, Alfred L M Bothwell
Jun 8, 2021·Frontiers in Immunology·Hang Yin ChuGe Zhang
Dec 11, 2021·Journal of Leukocyte Biology·Min Hee ParkWook-Jin Chae

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