Elevated central venous pressure is associated with increased mortality and acute kidney injury in critically ill patients: a meta-analysis

Critical Care : the Official Journal of the Critical Care Forum
Chuan-Yu ChenWan-Jie Gu

Abstract

The association of central venous pressure (CVP) and mortality and acute kidney injury (AKI) in critically ill adult patients remains unclear. We performed a meta-analysis to determine whether elevated CVP is associated with increased mortality and AKI in critically ill adult patients. We searched PubMed and Embase through June 2019 to identify studies that investigated the association between CVP and mortality and/or AKI in critically ill adult patients admitted into the intensive care unit. We calculated the summary odds ratio (OR) and 95% CI using a random-effects model. Fifteen cohort studies with a broad spectrum of critically ill patients (mainly sepsis) were included. On a dichotomous scale, elevated CVP was associated with an increased risk of mortality (3 studies; 969 participants; OR, 1.65; 95% CI, 1.19-2.29) and AKI (2 studies; 689 participants; OR, 2.09; 95% CI, 1.39-3.14). On a continuous scale, higher CVP was associated with greater risk of mortality (5 studies; 7837 participants; OR, 1.10; 95% CI, 1.03-1.17) and AKI (6 studies; 5446 participants; OR, 1.14; 95% CI, 1.06-1.23). Furthermore, per 1 mmHg increase in CVP increased the odds of AKI by 6% (4 studies; 5150 participants; OR, 1.06; 95% CI, 1.01-1.12). Furthe...Continue Reading

References

Jul 12, 2002·Statistics in Medicine·Julian P T Higgins, Simon G Thompson
Oct 23, 2002·Journal of Applied Physiology·George L Brengelmann
Sep 6, 2003·BMJ : British Medical Journal·Julian P T HigginsDouglas G Altman
Apr 28, 2004·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Itir YegenagaNorbert Lameire
Feb 14, 2009·Journal of the American College of Cardiology·Wilfried MullensW H Wilson Tang
Jun 15, 2010·Current Opinion in Critical Care·John R Prowle, Rinaldo Bellomo
Jun 15, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Daniel A Beard, Eric O Feigl
Oct 31, 2012·Critical Care : the Official Journal of the Critical Care Forum·Sheldon Magder
Dec 3, 2013·Critical Care : the Official Journal of the Critical Care Forum·Matthieu LegrandDidier Payen
May 28, 2015·Journal of Critical Care·Benjamin T WongRinaldo Bellomo
Jul 26, 2015·Clinical Journal of the American Society of Nephrology : CJASN·Mario RaimundoMarlies Ostermann
Jan 21, 2016·Clinical Journal of the American Society of Nephrology : CJASN·Kenneth P ChenJohn Danziger
Jul 1, 2017·Journal of Critical Care·Xiaoting WangLongxiang Su
Nov 23, 2018·Journal of Critical Care·Johannes P C van den AkkerC A den Uil

❮ Previous
Next ❯

Citations

Feb 7, 2021·Nature Reviews. Nephrology·Holger ScholzPontus B Persson
Jul 7, 2021·Korean Circulation Journal·Sung Yoon Lim, Sejoong Kim
Aug 23, 2021·Journal of Cardiothoracic and Vascular Anesthesia·Gabriela PetteyPalesa Motshabi Chakane
Nov 3, 2021·Pediatric Transplantation·Claudia A AlgazeSeth A Hollander

❮ Previous
Next ❯

Software Mentioned

Stata
Excel

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.