PMID: 2116736Jul 1, 1990Paper

Elevated cerebroside antibody levels in human visceral and cutaneous leishmaniasis, Trypanosoma rangeli infection, and chronic Chagas' disease

The American Journal of Tropical Medicine and Hygiene
J L Avila, M Rojas

Abstract

A natural cerebroside (antiC) IgM antibody was found at relatively high levels in the serum of every healthy individual studied. The reactivity of the antibody was assessed by using highly purified bovine brain galactocerebroside (galC) or human glucocerebroside (gluC) as antigen. The importance of fatty acid moiety of galC in antigen-antibody reaction was demonstrated by low immunoreactivity using 1-beta-D-galactosyl sphingosine (GS) as antigen and by the absence of absorption to GS-bearing liposomes. The presence of alpha-hydroxy and non-hydroxy fatty acids in galC did not modify its immunoreactivity. Cerebroside antibody binding activity was only partially blocked by 0.5 M galactose or alpha- and beta-methylgalactopyranoside, suggesting poor specificity of antiC for a specific glycosidic residue or linkage. In fact, liposome-bearing gluC absorbed galC. AntiC did not adsorb on rabbit, guinea pig, or human erythrocytes (RBC), but absorbed strongly on rat RBC. Elevated antibody levels were found in 57% of Kala azar patients, 56% of Trypanosoma rangeli-infected patients, 30% of chronic chagasic patients, and 20% of cutaneous leishmaniasis patients, but were not found in 16 other inflammatory or infectious diseases studied. This ...Continue Reading

Citations

Sep 17, 2020·Revista Da Sociedade Brasileira De Medicina Tropical·Taciana de Souza BayãoRodrigo Siqueira-Batista
Feb 26, 2000·Clinical and Experimental Immunology·M GirardM O Jauberteau
Aug 26, 2003·Memórias do Instituto Oswaldo Cruz·M T PaláuC A Zúñiga
Mar 3, 1994·Biochimica Et Biophysica Acta·J P VosB M Gadella

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