PMID: 9433409Jan 1, 1997Paper

Elevated cerebrospinal fluid substance P-like immunoreactivity in patients with painful osteoarthritis, but not in patients with rhizopatic pain from a herniated lumbar disc

Scandinavian Journal of Rheumatology
C LindhF Nyberg

Abstract

Cerebrospinal fluid (CSF) levels of substance P like immunoreactivity (SPLI) were determined in 11 patients with painful osteoarthritis in hip or knee, 9 patients with rhizopatic pain from a herniated lumbar disc, and in 9 healthy volunteers without pain. The patients with osteoarthritis had increased levels of SPLI in CSF (p < 0.001) compared to the controls. A positive correlation was also seen between the CSF SPLI and the degree of pain. At a second lumbar puncture 5 months after operation, SPLI had decreased, but was still significantly higher than in the controls. No difference in CSF SPLI was seen in the patients with herniated lumbar disc compared to the controls, neither before treatment, nor at follow up CSF postoperatively. The results suggest that nociceptive joint pain is consistent with increased SPLI in CSF. Differences in SPLI in CSF may be useful to differentiate pain from various origin, and may also increase our understanding of different pain mechanisms.

References

Jan 1, 1992·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·I K AshtonS M Eisenstein
May 1, 1994·Headache·J W ClarkC Gallagher
Mar 1, 1994·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·I K AshtonS M Eisenstein
Jun 6, 1931·The Journal of Physiology·U S V Euler, J H Gaddum

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Citations

Jul 21, 2007·Rheumatology International·Gerhard K M Endresen
Nov 8, 2003·Current Pain and Headache Reports·Karl G Henriksson
Sep 11, 2002·Regulatory Peptides·J P QuinnJ M Coulson
Nov 10, 2004·Spine·Michael CornefjordHelena Brisby
Jan 17, 2007·Spine·Hirohito TakeuchiToshihiko Yamashita
Oct 15, 2013·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Emmanuel BäckrydBjörn Gerdle
Jul 3, 2007·Best Practice & Research. Clinical Rheumatology·Henning Bliddal, Bente Danneskiold-Samsøe
Feb 15, 2011·European Journal of Pain : EJP·Elle L ParksA Vania Apkarian
Aug 14, 2003·The Orthopedic Clinics of North America·Helena Brisby
Nov 16, 2004·The Spine Journal : Official Journal of the North American Spine Society·Casey K Lee, Vijay K Goel
Jun 14, 2005·The Orthopedic Clinics of North America·Peter FrelinghuysenFrank P Cammisa
Jan 18, 2005·The Spine Journal : Official Journal of the North American Spine Society·Seth C Gamradt, Jeffrey C Wang
Dec 7, 2018·The European Journal of Neuroscience·Lydia HannouValérie Mongrain
Jan 6, 2007·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Susan ChubinskayaDavid C Rueger
Jul 25, 2018·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Birgitta Gatenholm, Mats Brittberg
Mar 18, 2020·Frontiers in Endocrinology·Fu-Xing-Zi LiLing-Qing Yuan
Mar 19, 2021·Bone Research·Yan HuJiacan Su

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