Elevated circulating T cell subsets and cytokines expression in patients with rheumatoid arthritis.

Clinical Rheumatology
Haiyan ZhouLong Li

Abstract

This study aimed to assess the role of different subsets of circulating follicular helper T cells (Tfh), central memory (TCM), effector memory (TEM), Naïve T, chemokines, and cytokines in the pathogenesis of rheumatoid arthritis (RA). Blood samples from RA patients (n = 44) and healthy controls (n = 37) were analyzed. The frequencies of circulating Tfh, TCM, TEM, and Naïve T cell subsets were enumerated, and the expression of co-stimulatory molecules, such as inducible co-stimulator (ICOS) and programmed death-1 (PD1), on these cells was evaluated by flow cytometry. The disease state in RA patients was assessed using the DAS28. Concentrations of C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), anti-cyclic citrullinated peptide (anti-CCP), and rheumatoid factor (RF) were measured. Cytokines and chemokines, such as IL-1β, TNF-α, IL-4, IL-6, IL-9, IL-17A, MCP-1, IL-10, IL-12p70, and IL-21, were measured by a cytometric beads array assay. The percentages of circulating PD1+ICOS+ Tfh, PD1+ICOS+ TEM, and PD1+ICOS+ TCM of PBMCs from RA patients were higher than those in healthy controls. Furthermore, expression of circulating PD1+ICOS+ Tfh, PD1+ICOS+ TEM, and PD1+ICOS+ TCM showed a positive correlation with DAS28. In ad...Continue Reading

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Citations

Nov 5, 2020·Clinical Science·Maarten M SteinzJohanna T Lanner
Sep 9, 2020·Seminars in Arthritis and Rheumatism·Charlotte LucasPatricia Amé
Apr 19, 2021·Journal of Leukocyte Biology·Andrew P Hart, Terri M Laufer
Apr 22, 2021·Cellular and Molecular Life Sciences : CMLS·Jian LuShengjun Wang
Sep 20, 2021·IUBMB Life·Ramin HosseinzadehHamed Mohammadi
Jul 9, 2021·International Immunopharmacology·Sanjiv SinghV Ravichandiran

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