Elevated Circulatory Levels of Microparticles Are Associated to Lung Fibrosis and Vasculopathy During Systemic Sclerosis.

Frontiers in Immunology
Damien LeleuMarie-Elise Truchetet

Abstract

Microparticles (MPs) are vesicular structures that derive from multiple cellular sources. MPs play important roles in intercellular communication, regulation of cell signaling or initiation of enzymatic processes. While MPs were characterized in Systemic Sclerosis (SSc) patients, their contribution to SSc pathogenesis remains unknown. Our aim was to investigate the potential role of MPs in SSc pathophysiology and their impact on tissue fibrosis. Ninety-six SSc patients and 37 sex-matched healthy donors (HD) were enrolled in this study in order to quantify and phenotype their plasmatic MPs by flow cytometry. The ability of MPs purified from SSc patients and HD controls to modulate fibroblast's extra-cellular matrix genes expression was evaluated in vitro by reverse transcriptase quantitative polymerase chain reaction. SSc patients exhibited a higher concentration of circulatory MPs compared to HD. This difference was exacerbated when we only considered patients that were not treated with methotrexate or targeted disease-modifying antirheumatic drugs. Total circulatory MPs were associated to interstitial lung disease, lung fibrosis and diminished lung functional capacity, but also to vascular involvement such as active digital ul...Continue Reading

References

Jan 1, 1995·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·J K LackiW Müller
Aug 30, 2001·Cell Death and Differentiation·G DeneckerP Vandenabeele
May 10, 2003·Rheumatology International·Amita Aggarwal, Ramnath Misra
May 22, 2003·Annals of the Rheumatic Diseases·R J U LoriesF P Luyten
Mar 29, 2008·American Journal of Respiratory and Critical Care Medicine·Nicole S L GohAthol U Wells
Dec 7, 2010·Immunologic Research·David S PisetskyAnirudh J Ullal
Mar 13, 2014·Journal of Thrombosis and Haemostasis : JTH·N ArraudA R Brisson
Oct 8, 2014·Annual Review of Cell and Developmental Biology·Marina ColomboClotilde Théry
Mar 18, 2015·Arthritis & Rheumatology·Niloufar KavianFrédéric Batteux
Nov 12, 2015·Autoimmunity Reviews·Delphine TurpinPierre Duffau
Oct 28, 2016·Arthritis & Rheumatology·Marie-Elise TruchetetUNKNOWN Fédération Hospitalo-Universitaire ACRONIM
Dec 13, 2016·Annals of the Rheumatic Diseases·Otylia Kowal-BieleckaUNKNOWN EUSTAR Coauthors
Apr 11, 2018·Autoimmunity Reviews·Marc ScherlingerPatrick Blanco
Jul 27, 2018·Science Translational Medicine·Norma MaugeriAngelo A Manfredi
Feb 13, 2019·Respirology : Official Journal of the Asian Pacific Society of Respirology·Matthew R LammiA Hamid Boulares
Mar 15, 2019·Current Opinion in Rheumatology·David RoofehDinesh Khanna

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Methods Mentioned

BETA
flow cytometry
PCR

Software Mentioned

GraphPad Prism

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