Elevated concentration of cerebrospinal fluid tissue transglutaminase in Parkinson's disease indicating apoptosis

Movement Disorders : Official Journal of the Movement Disorder Society
Istvan VermesClemens Haanen

Abstract

Tissue transglutaminase (tTG) is activated during the apoptotic cell death cascade and plays a key role in the formation of apoptotic bodies. We found significant elevation of tTG concentration in the cerebrospinal fluid (CSF) of 54 patients with Parkinson's disease (PD) compared with that measured in 34 control subjects, thus showing increased neural cell apoptosis in patients with PD.

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Citations

Jul 30, 2011·Amino Acids·Claudio TabolacciSimone Beninati
Oct 16, 2010·Biomarkers in Medicine·Jakob NyhlénHenrik Zetterberg
Feb 18, 2010·Future Neurology·Thomas M JeitnerArthur Jl Cooper
Sep 10, 2014·Proceedings of the National Academy of Sciences of the United States of America·Kozo HamadaKatsuhiko Mikoshiba
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May 5, 2009·Movement Disorders : Official Journal of the Movement Disorder Society·Brit Mollenhauer, Claudia Trenkwalder
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Jun 5, 2010·Brain Pathology·Min ShiJing Zhang
Jul 5, 2008·Expert Review of Molecular Diagnostics·Hayrettin TumaniJohannes Brettschneider
Jun 28, 2014·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Hilary GrossoM Maral Mouradian
Jan 13, 2015·Clinical Chemistry and Laboratory Medicine : CCLM·Rutong RenXiaoping Pu
Mar 21, 2019·Animal Models and Experimental Medicine·Kewei WangMang Li
Jul 10, 2013·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Yu-Tao LiuJun-Ling Wang
Jan 13, 2021·Neural Regeneration Research·Jie ZhangM Maral Mouradian
Jun 6, 2020·Neuroscience·Jie ZhangM Maral Mouradian
Mar 9, 2021·Proteomics. Clinical Applications·Justin McKetneyJoshua J Coon
Aug 28, 2021·International Journal of Molecular Sciences·Anja Schulze-KrebsStephan von Hörsten
Oct 6, 2021·Expert Opinion on Therapeutic Targets·Jeffrey W Keillor, Gail V W Johnson

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