Elevated concentration of cytokines in aqueous in post-vitrectomy eyes

Clinical & Experimental Ophthalmology
RuiPing GuGeZhi Xu

Abstract

We aim to study the level of inflammatory cytokines in aqueous of post-vitrectomy eyes. Aqueous samples were obtained from post-vitrectomy eyes that underwent cataract surgery. Samples from age-related cataract patients were also collected as controls. The concentrations of cytokines were measured by array-based multiplex sandwich enzyme-linked immunosorbent assay system and microparticle-based multiplex cytokine assay. Eighteen post-vitrectomy eyes from 18 patients were included; all received one vitrectomy with gas injection for rhegmatogenous retinal detachment. The mean interval between vitrectomy and cataract surgery was 22.33 months (range 6 to 80). Primary results show that in post-vitrectomy eyes the levels of many cytokines, such as B-lymphocyte chemo-attractant, I-309, interleukin (IL)-6, IL-8, interferon γ-induced protein-10 and intercellular adhesion molecule 1, were higher than control. Further analysis demonstrated that the levels of IL-8, interferon γ-induced protein-10 and intercellular adhesion molecule 1 were significantly elevated in post-vitrectomy eyes, even after the subjects were divided by their refractive state. The concentrations of some cytokines were increased in the anterior chambers of post-vitrect...Continue Reading

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Citations

Feb 2, 2017·Ocular Immunology and Inflammation·Hassan Ghasemi
Jul 3, 2019·Journal of Cataract and Refractive Surgery·Eleonora FavuzzaRita Mencucci
Oct 10, 2021·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Jae Hyuck LeeHungwon Tchah

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