Elevated Creatine Kinase due to Potential Drug Interaction With Ticagrelor and Atorvastatin

Journal of Pharmacy Practice
Janna C Beavers

Abstract

Ticagrelor and atorvastatin are commonly used medications in the management of acute coronary syndrome and percutaneous intervention. This is a report of a patient case of a potential drug interaction leading to the use of alternative therapy. A 58-year-old male presented for cardiac catheterization following an abnormal stress test. He underwent placement of a drug-eluting stent and was started on ticagrelor. Three months later, he was noted to have elevated creatine kinase (CK), thought to be related to a potential drug-drug interaction between ticagrelor and atorvastatin. Ticagrelor was discontinued and he was successfully transitioned to clopidogrel. CK returned to normal within weeks of this change. Pharmacokinetic studies have demonstrated a potential interaction between ticagrelor and atorvastatin but have not been deemed clinically significant. To date, only one other case report has been published discussing this interaction and consideration of alternative therapy. This case report is unique, with ticagrelor being the only new medication added prior to the abnormal CK finding. A probable drug-drug interaction occurred with concomitant ticagrelor and atorvastatin. While this interaction may not always be clinically sig...Continue Reading

References

Mar 1, 1996·Journal of Clinical Pharmacology·D M GibsonL R Whitfield
Mar 29, 2007·The Annals of Pharmacotherapy·John R HornLingtak-Neander Chan
Sep 1, 2009·The New England Journal of Medicine·Lars WallentinMona Thorsén
Aug 28, 2012·European Journal of Clinical Pharmacology·Renli TengKathleen A Butler
Dec 19, 2012·Circulation·Patrick T O'GaraUNKNOWN American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines
May 25, 2015·Journal of the American Pharmacists Association : JAPhA·Kazuhiko KidoJonathan A Bain
Oct 19, 2016·Circulation·Barbara S WigginsUNKNOWN American Heart Association Clinical Pharmacology Committee of the Council on Clinical Cardiology; Council on Hypertension; C

❮ Previous
Next ❯

Citations

Jan 21, 2020·Expert Opinion on Pharmacotherapy·Jinhao HuangRongcai Jiang
Jul 8, 2020·Pharmaceutical Biology·Jia ChongJiefu Yang

❮ Previous
Next ❯

Methods Mentioned

BETA
coronary artery bypass

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions
Sanjiv Sharma, Brijesh Bhambi
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine
Testu Yamaguchi
The Annals of Pharmacotherapy
Sarah R PeppardRichard Beddingfield
The New Zealand Medical Journal
Patrick Gladding, Mark Webster
© 2022 Meta ULC. All rights reserved