Elevated CRP levels predict poor outcome and tumor recurrence in patients with thymic epithelial tumors: A pro- and retrospective analysis

Oncotarget
S JanikBernhard Moser

Abstract

Scarce information exists on the pathogenesis of thymic epithelial tumors (TETs), comprising thymomas, thymic carcinomas (TCs) and neuroendocrine tumors. C-reactive protein (CRP) increases during certain malignancies. We aimed to investigate the clinical relevance of CRP in patients with TETs. Pretreatment CRP serum concentrations were significantly elevated in patients with TETs, particularly TCs and metastatic TETs. After complete tumor resection CRP serum concentrations were decreased (p = 0.135) but increased significantly in case of tumor recurrence (p = 0.001). High pretreatment CRP was associated with significantly worse 5- and 10-year freedom-from recurrence (FFR) (p = 0.010) and was a negative prognostic factor for FFR (HR 3.30; p = 0.015). IL-6 (not IL-1β) serum concentrations were significantly elevated in patients with TETs but we did not detect CRP tissue expression in TETs. Pretreatment CRP serum concentrations were retrospectively analyzed from 128 surgical patients (1990-2015). In a subset of 68 patients longitudinal analysis of CRP was performed. Additionally, immunohistochemical tumor CRP expression and serum concentrations of interleukin (IL)-6 and IL-1β were measured. Hence, diagnostic measurement of serum C...Continue Reading

References

Jul 1, 1992·Immunology Today·A MantovaniL Ruco
Feb 11, 1999·The New England Journal of Medicine·C Gabay, I Kushner
Apr 6, 2004·The Annals of Thoracic Surgery·Kazuya KondoYasumasa Monden
Apr 16, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Philipp StröbelAlexander Marx
Sep 30, 2005·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·S EndoY Sohara
Oct 14, 2005·Kidney International·Wolfram J JabsChristian Doehn
Nov 15, 2006·Clinical and Experimental Immunology·D G HaiderM Wolzt
Sep 23, 2008·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Masaru SuzukiMasaharu Nishimura
May 28, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Brandon L PierceCornelia M Ulrich
May 11, 2010·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Caroline O'DowdRobert Milroy
Oct 28, 2010·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·James HuangPatrick J Loehrer
May 31, 2011·Frontiers in Bioscience (Landmark Edition)·Anastasia Z KaleaBarry I Hudson
Jun 21, 2011·Journal of the National Cancer Institute·Sharon R PineCurtis C Harris
Sep 29, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Frank C DetterbeckCesar Moran
May 29, 2012·The Annals of Thoracic Surgery·Masatsugu HamajiK Robert Shen
Jun 16, 2012·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Mi Kyung BaeKyung Young Chung
Sep 6, 2012·Chest·Asha SarmaC Gregory Elliott
Mar 29, 2013·Autoimmunity Reviews·Alexander MarxPhilipp Ströbel
Jul 31, 2013·PloS One·Yesim Gökmen-PolarSunil Badve
Feb 1, 2014·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Enrico RuffiniUNKNOWN European Association of Thoracic Surgeons (ESTS) Thymic Working Group
Apr 17, 2014·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Enrico RuffiniUNKNOWN European Society of Thoracic Surgeons Thymic Working Group
Apr 26, 2014·Genes, Chromosomes & Cancer·Philipp StröbelAlexander Marx
Jul 1, 2014·Nature Genetics·Iacopo PetriniGiuseppe Giaccone
Oct 14, 2014·The Journal of Thoracic and Cardiovascular Surgery·Pier Luigi FilossoUNKNOWN European Society of Thoracic Surgeons Thymic Group Steering Committee
Nov 14, 2014·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Alberto SandriEnrico Ruffini
Jan 24, 2015·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Cleo-Aron WeisUNKNOWN Contributors to the ITMIG Retrospective Database
Mar 11, 2015·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Giuseppe MarulliFederico Rea
Mar 31, 2015·Journal of Pathology and Translational Medicine·Jin Ho ShinEunsil Yu
Jun 11, 2015·International Journal of Oncology·Sha SheYixuan Yang
Jun 25, 2015·Interactive Cardiovascular and Thoracic Surgery·Jie DaiGening Jiang
Aug 22, 2015·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Alexander MarxPhilipp Ströbel
Feb 3, 2016·Therapeutics and Clinical Risk Management·Christos AsteriouNikolaos Barbetakis
Nov 16, 2016·Pathology Oncology Research : POR·Franz EnknerLeonhard Müllauer

❮ Previous
Next ❯

Citations

Jul 22, 2018·International Journal of Radiation Biology·Birşen BilgiciBegüm K Engiz
Aug 12, 2018·Scientific Reports·Mohsen DorrakiDerek Abbott
Dec 11, 2019·Scientific Reports·Cecilia VeraarBernhard Moser
Nov 21, 2018·Journal of Cardiothoracic Surgery·Piergiorgio MurianaGiampiero Negri
Nov 24, 2019·Scientific Reports·Stefan JanikBernhard Moser

❮ Previous
Next ❯

Methods Mentioned

BETA
blood draw
surgical resection
ELISA

Software Mentioned

SPSS
ITMIG

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Revue des maladies respiratoires
V Thomas De Montpréville
Prensa médica argentina
G A LACOUR
European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology
E RintalaJ Nikoskelainen
© 2022 Meta ULC. All rights reserved