Elevated D-Dimer Is Associated with Multiple Clinical Outcomes in Hospitalized Covid-19 Patients: a Retrospective Cohort Study

SN Comprehensive Clinical Medicine
Jason WagnerAhmad Farooq

Abstract

D-dimer is a prognostic marker for Covid-19 disease mortality and severity in hospitalized patients; however, little is known about the association between D-dimer and other clinical outcomes. The aim of this paper was to define a threshold of D-dimer to use in hospitalized patients with Covid-19 and to assess its utility in prognosticating in-hospital mortality, development of an acute kidney injury (AKI), and need for hemodialysis, vasopressors, or intubation. This is a single-center, retrospective, cohort review study of 100 predominantly minority patients (94%) hospitalized with Covid-19. The electronic medical record system was used to collect data. Receiver operating characteristics (ROC) and area under the curve (AUC) analysis were used to determine optimal thresholds of peak D-dimer, defined as the highest D-dimer obtained during admission that was clinically meaningful. Odds ratios were then used to assess the relationship between peak D-dimer thresholds and clinical outcomes. D-dimer > 2.1 μg/mL and > 2.48 μg/mL had > 90% sensitivity and > 50% specificity for predicting need for vasopressors (AUC 0.80) or intubation (AUC 0.83) and in-hospital mortality (AUC 0.89), respectively. Additionally, D-dimer > 4.86 μg/mL had a...Continue Reading

References

Nov 4, 2017·Journal of the American College of Cardiology·Jeffrey I WeitzJohn W Eikelboom
Feb 29, 2020·The New England Journal of Medicine·Wei-Jie GuanUNKNOWN China Medical Treatment Expert Group for Covid-19
Apr 6, 2020·Kidney International·Yichun ChengGang Xu
Apr 20, 2020·Journal of Thrombosis and Haemostasis : JTH·Litao ZhangZhenlu Zhang
Apr 23, 2020·JAMA : the Journal of the American Medical Association·Safiya RichardsonTheodoros P Zanos
Apr 25, 2020·JAMA : the Journal of the American Medical Association·John J Marini, Luciano Gattinoni
Apr 28, 2020·Blood·Jean M Connors, Jerrold H Levy
May 6, 2020·Journal of the American Society of Nephrology : JASN·Daniel BatlleUNKNOWN COVID-19 and ACE2 in Cardiovascular, Lung, and Kidney Working Group
May 12, 2020·JAMA : the Journal of the American Medical Association·Monica Webb HooperEliseo J Pérez-Stable
May 16, 2020·Frontiers in Public Health·Jian-Min JinJin-Kui Yang
Jul 12, 2020·Journal of the American College of Cardiology·Yader SandovalAllan S Jaffe
Aug 28, 2020·Thrombosis Research·Angelo PorfidiaMarcello Di Nisio
Oct 13, 2020·SN Comprehensive Clinical Medicine·Lai Chee ChowHock Hin Chua
Oct 14, 2020·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·Geoffrey D Wool, Jonathan L Miller

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Citations

Jul 18, 2021·Journal of Thrombosis and Thrombolysis·Luis García de Guadiana-RomualdoAmparo Galán Ortega

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