Elevated dietary magnesium prevents connective tissue mineralization in a mouse model of pseudoxanthoma elasticum (Abcc6(-/-)).

The Journal of Investigative Dermatology
Jennifer LaRussoJouni Uitto

Abstract

Pseudoxanthoma elasticum (PXE) is an autosomal recessive multisystem disorder characterized by ectopic connective tissue mineralization, with clinical manifestations primarily in the skin, eyes, and cardiovascular system. There is considerable, both intra- and interfamilial, variability in the spectrum of phenotypic presentation. Previous studies have suggested that mineral content of the diet may modify the severity of the clinical phenotype in PXE. In this study, we utilized a targeted mutant mouse (Abcc6(-/-)) as a model system for PXE. We examined the effects of changes in dietary phosphate and magnesium on the mineralization process using calcification of the connective tissue capsule surrounding the vibrissae as an early phenotypic biomarker. Mice placed on custom-designed diets either high or low in phosphate did not show changes in mineralization, which was similar to that noted in Abcc6(-/-) mice on control diet. However, mice placed on diet enriched in magnesium (fivefold) showed no evidence of connective tissue mineralization in this mouse model of PXE. The inhibitory capacity of magnesium was confirmed in a cell-based mineralization assay system in vitro. Collectively, our observations suggest that assessment of die...Continue Reading

Associated Clinical Trials

References

Oct 1, 1984·American Journal of Medical Genetics·W A RenieS L Fine
Sep 2, 2005·Molecular and Cellular Biology·John F KlementJouni Uitto
Oct 4, 2005·Journal of the American Academy of Dermatology·Daniel W ShererMark Lebwohl
Apr 8, 2006·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·R K RudeJ Kilburn
Jan 1, 2008·Expert Opinion on Medical Diagnostics·Rajmohan MuraliRichard A Scolyer
Jan 1, 2008·Expert Opinion on Medical Diagnostics·Ellen G PfendnerSharon F Terry

❮ Previous
Next ❯

Citations

Sep 29, 2009·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Qiaoli Li, Jouni Uitto
Feb 24, 2010·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Theo G M F GorgelsArthur A B Bergen
Jul 14, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Fatih KircelliJutta Passlick-Deetjen
Jan 28, 2010·Pharmacological Reviews·Curtis D Klaassen, Lauren M Aleksunes
Apr 16, 2014·Laboratory Investigation; a Journal of Technical Methods and Pathology·Qiaoli LiJouni Uitto
Nov 16, 2013·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Renu AgarwalPuneet Agarwal
Feb 24, 2016·The Journal of Investigative Dermatology·Qiaoli LiJouni Uitto
Nov 17, 2012·The Journal of Investigative Dermatology·Qiaoli Li, Jouni Uitto
Dec 1, 2009·Kidney International. Supplement·Vincent M BrandenburgMarkus Ketteler
Mar 2, 2010·Ophthalmology·Peter Charbel IssaHendrik P N Scholl
Jan 30, 2010·Annales de dermatologie et de vénéréologie·J Mazereeuw-Hautier
Jun 12, 2013·The American Journal of Pathology·Alexander H KirschPhilipp Eller
Sep 12, 2015·Intractable & Rare Diseases Research·Barbara MarconiAnnamaria Offidani
Apr 4, 2012·The American Journal of Pathology·Yannick Le CorreLudovic Martin
Dec 25, 2009·The Journal of Investigative Dermatology·Jouni UittoQiujie Jiang
May 16, 2013·The Journal of Investigative Dermatology·Jouni UittoSharon F Terry
Mar 26, 2011·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Jennifer LaRussoJouni Uitto
Jun 12, 2013·The British Journal of Dermatology·Q LiL Schachner
Jul 31, 2013·Matrix Biology : Journal of the International Society for Matrix Biology·Qiaoli LiJouni Uitto
Mar 17, 2012·Matrix Biology : Journal of the International Society for Matrix Biology·N Beril KavukcuogluJouni Uitto
May 13, 2015·Nature Reviews. Nephrology·Ziad A Massy, Tilman B Drüeke
May 15, 2013·The American Journal of Pathology·Qiaoli Li, Jouni Uitto
Aug 1, 2012·The American Journal of Pathology·Qiaoli LiJouni Uitto
Sep 12, 2017·International Journal of Molecular Sciences·Guillaume FavreGeorges Lefthériotis
Oct 23, 2010·Retina·Sandrine A ZweifelRichard F Spaide
Feb 12, 2010·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Alain Hovnanian
Feb 1, 2011·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·J Frank, P Poblete-Gutiérrez
Jan 1, 2013·Expert Review of Endocrinology & Metabolism·Mie Rostved RasmussenSøren Kragh Moestrup
Nov 11, 2014·Expert Opinion on Orphan Drugs·Jouni UittoSharon F Terry
Sep 13, 2018·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S Akhtar AliP Pitukcheewanont
Jun 7, 2017·Current Osteoporosis Reports·Yvonne Nitschke, Frank Rutsch
Nov 2, 2020·FEBS Letters·Shana VerschuereOlivier M Vanakker
May 1, 2021·International Journal of Molecular Sciences·Briana K ShimadaOlivier Le Saux

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.