Elevated dopamine D1 receptor availability in striatum of Göttingen minipigs after electroconvulsive therapy

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
Anne M LandauDoris J Doudet

Abstract

Electroconvulsive therapy (ECT), a direct form of brain stimulation, is an effective antidepressant. We hypothesized that the beneficial effects of ECT are mediated by increased dopaminergic neurotransmission, in which the baseline activity of D1 receptors may predict the response to ECT. We established a novel model of brain stimulation in Göttingen minipigs based on the protocol of ECT applied in humans. With positron emission tomography (PET), we determined a measure of dopaminergic neurotransmission with the dopamine D1 receptor antagonist [11C]SCH23390. Seven minipigs were anesthetized and completed PET at baseline, prior to the onset of ECT treatment, and at 24-48 h and 8-10 days after the end of a clinical course of ECT, consisting of 10 ECT sessions over a 3.5-week period. In all pigs, the binding of [11C]SCH23390 to striatal D1 receptors had increased by 24-48 h after ECT, and in most, binding returned towards baseline at 8-10 days. Increased binding was observed in inverse proportion to baseline binding rates. Increased binding to dopamine D1 receptors suggests facilitation of dopaminergic neurotransmission, which may contribute to the therapeutic effects of ECT. Importantly, the baseline binding capacity of D1 recept...Continue Reading

References

Jan 1, 1991·Movement Disorders : Official Journal of the Movement Disorder Society·R Faber, M R Trimble
Aug 22, 1989·European Journal of Pharmacology·L J FochtmannW Z Potter
Nov 1, 1989·The American Journal of Psychiatry·R DouyonJ Rotrosen
Jun 1, 1996·Journal of Neurology, Neurosurgery, and Psychiatry·S Pridmore, C Pollard
Mar 14, 2001·Journal of Affective Disorders·M Fink
Nov 8, 2001·NeuroImage·H WatanabeUNKNOWN DaNeX Study Group
Apr 17, 2004·The Journal of ECT·Daniel PagninGiovanni Battista Cassano
Apr 12, 2005·Journal of Affective Disorders·Paul WillnerSpilios Argyropoulos
May 2, 2007·The British Journal of Psychiatry : the Journal of Mental Science·Trine Munk-OlsenRaben Rosenberg
Oct 9, 2007·Brain Research·Daniela V F RosaMarco A Romano-Silva
Jul 30, 2009·Expert Opinion on Emerging Drugs·Sidney H Kennedy, Sakina J Rizvi
Oct 15, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Anne M LandauDoris J Doudet
Mar 2, 2011·Journal of Neural Transmission·Paloma Fernández-CorcueraPeter McKenna
Feb 14, 2012·Neuro-degenerative Diseases·Anne M LandauDoris J Doudet
Jul 14, 2012·Veterinary Anaesthesia and Analgesia·R Eddie CluttonMichael Eddleston
Oct 2, 2013·BioMed Research International·Aage K O AlstrupDoris J Doudet

❮ Previous
Next ❯

Citations

Oct 26, 2018·Scientific Reports·Thea P LillethorupAnne M Landau
Jun 10, 2020·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Majken Borup ThomsenAnne M Landau
Jan 30, 2020·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Anne M LandauMichael Winterdahl

❮ Previous
Next ❯

Software Mentioned

GraphPad Prism
Montreal

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.