Elevated ejection-phase myocardial wall stress in children with chronic kidney disease

Hypertension
Haotian GuPhil J Chowienczyk

Abstract

Myocardial wall stress (MWS) is thought to be the mechanical stimulus to ventricular hypertrophy. The objective of this study was to examine whether MWS is elevated in children with chronic kidney disease (CKD) who are at high risk of developing adverse cardiovascular events related to left ventricular (LV) hypertrophy. MWS, a function of left ventricular pressure, myocardial wall volume, and cavity volume, was obtained using carotid tonometry to estimate ventricular pressure and 2-dimensional transthoracic echocardiographic wall-tracking to obtain LV cavity and wall volumes. Ninety-two children (50 boys) aged 11.2±3.2 (mean±SD) years, including healthy controls (n=16), and those with CKD disease divided into 3 groups according to estimated glomerular filtration rate (mL/min per 1.73 m2) >90 (CKD 1, n=26), 60 to 90(CKD 2, n=23), and <60 (CKD≥3, n=27) were studied. There was no significant difference in age, height, weight, central or peripheral blood pressure, LV mass, or mass index in the 4 study groups. By contrast, peak, mean, and end-systolic MWS were higher in children with CKD and increased across stages of CKD (peak MWS, 338.8±18.5 and 397.5±14.3 s/cm2 in controls and CKD≥3, respectively; P=0.01). Higher systolic MWS was...Continue Reading

References

Jul 1, 1975·The Journal of Clinical Investigation·W GrossmanL P McLaurin
Oct 1, 1968·The American Journal of Cardiology·W P HoodE L Rolett
Feb 19, 2002·Kidney International·Jaap W GroothoffHugo S A Heymans
Dec 6, 2003·Hypertension·Aram V ChobanianUNKNOWN National High Blood Pressure Education Program Coordinating Committee
Apr 7, 2004·Circulation·Norbert FreyJoseph A Hill
Jun 25, 2004·The New England Journal of Medicine·Stephen P McDonaldUNKNOWN Australian and New Zealand Paediatric Nephrology Association
Aug 3, 2004·Pediatrics·UNKNOWN National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents
Nov 11, 2005·Journal of the American Society of Nephrology : JASN·Maria Chiara MatteucciUNKNOWN ESCAPE Trial Group
Jan 12, 2007·Journal of the American Society of Nephrology : JASN·Marcello ChinaliUNKNOWN ESCAPE Trial Group
Apr 15, 2008·Current Opinion in Nephrology and Hypertension·Franz Schaefer
May 9, 2009·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Philip R KhouryThomas R Kimball
Jul 25, 2009·Journal of Hypertension·Empar LurbeUNKNOWN European Society of Hypertension
Nov 18, 2009·Journal of the American Society of Nephrology : JASN·Mark MitsnefesUNKNOWN CKiD Study Group
Dec 18, 2009·European Journal of Echocardiography : the Journal of the Working Group on Echocardiography of the European Society of Cardiology·John M SimpsonManish D Sinha
Aug 3, 2010·European Journal of Heart Failure·Amil M Shah, Scott D Solomon
Dec 1, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Manish D SinhaJohn M Simpson
Sep 14, 2011·Nature Reviews. Nephrology·Rukshana ShroffMark M Mitsnefes
Mar 3, 2012·Journal of the American Society of Nephrology : JASN·Mark M Mitsnefes
Jun 6, 2012·Hypertension·Julio A ChirinosUNKNOWN Asklepios Investigators

❮ Previous
Next ❯

Citations

Oct 25, 2016·Seminars in Dialysis·Aghogho Odudu, Christopher W McIntyre
May 20, 2017·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Shanmugakumar ChinnappaAndrew Mooney
Mar 10, 2017·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Rawan K RummanMichael Grattan
Apr 13, 2021·Clinical Kidney Journal·Shanmugakumar ChinnappaAndrew Mooney

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.