Elevated endogenous erythropoietin concentrations are associated with increased risk of brain damage in extremely preterm neonates

PloS One
Steven J KorzeniewskiELGAN study Investigators

Abstract

We sought to determine, in very preterm infants, whether elevated perinatal erythropoietin (EPO) concentrations are associated with increased risks of indicators of brain damage, and whether this risk differs by the co-occurrence or absence of intermittent or sustained systemic inflammation (ISSI). Protein concentrations were measured in blood collected from 786 infants born before the 28th week of gestation. EPO was measured on postnatal day 14, and 25 inflammation-related proteins were measured weekly during the first 2 postnatal weeks. We defined ISSI as a concentration in the top quartile of each of 25 inflammation-related proteins on two separate days a week apart. Hypererythropoietinemia (hyperEPO) was defined as the highest quartile for gestational age on postnatal day 14. Using logistic regression and multinomial logistic regression models, we compared risks of brain damage among neonates with hyperEPO only, ISSI only, and hyperEPO+ISSI, to those who had neither hyperEPO nor ISSI, adjusting for gestational age. Newborns with hyperEPO, regardless of ISSI, were more than twice as likely as those without to have very low (< 55) Mental (OR 2.3; 95% CI 1.5-3.5) and/or Psychomotor (OR 2.4; 95% CI 1.6-3.7) Development Indices ...Continue Reading

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Citations

Apr 14, 2017·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Elizabeth N AllredUNKNOWN ELGAN Study ADHD symptoms writing group for the ELGAN Study Investigators
Aug 15, 2018·Nature Reviews. Neurology·Steven J KorzeniewskiNigel Paneth
Feb 8, 2018·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Alan LevitonKarl C K Kuban
Oct 21, 2017·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Rafael C MagalhãesAna C Simões E Silva
Jun 5, 2020·Nursing Research·Marliese Dion NistRita H Pickler
Apr 21, 2018·Journal of Neuroinflammation·Ruth GussenhovenTim G A M Wolfs
May 31, 2019·Biological Research for Nursing·Marliese Dion Nist, Rita H Pickler
Jul 1, 2016·Developmental Medicine and Child Neurology·Tammy Z MovsasIra H Gewolb
Apr 2, 2020·BMC Neurology·Zunera ZareenEleanor J Molloy
Nov 14, 2020·Developmental Medicine and Child Neurology·Zunera ZareenEleanor J Molloy
Aug 1, 2021·Seminars in Fetal & Neonatal Medicine·Eman IsweisiUNKNOWN Newborn Brain Society Guidelines and Publications Committee

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