Elevated erythrocyte carbonic anhydrase activity is a novel clinical marker in hyperventilation syndrome

Clinical Chemistry and Laboratory Medicine : CCLM
Ying-Hock TengShun-Fa Yang


The aim of this study was to evaluate the erythrocyte carbonic anhydrase (CA) activity in patients with hyperventilation syndrome. A total of 71 patients with hyperventilation syndrome and 60 controls were recruited in this study for measurement of the erythrocyte CA activity. CA activity was analyzed from erythrocyte using CA esterase activity analysis. The erythrocyte CA activity was significantly elevated in the patients with hyperventilation syndrome compared to controls (31.07+/-1.37 U/g Hb vs. 24.67+/-0.99 U/g Hb, p=0.003). The standardized beta value and significant R(2) value of total CA activity for prediction of hyperventilation was 0.155 (p=0.016) and 0.024, respectively. Moreover, a significant negative correlation was found between total CA activity and partial pressure of carbon dioxide (PaCO(2)) (r=-0.185, p=0.03, n=131). Furthermore, the adjusted odds ratios for patients with hyperventilation were 11.6 (95% CI: 4.8-27.9) and 51.0 (95% CI: 5.8-445.2) for individuals with either PaCO(2)<or=28.1 mm Hg or CA activity >or=29.71 U/g hemoglobin (Hb), and for individuals with both PaCO(2)<or=28.1 mm Hg and CA activity >or=29.71 U/g Hb, respectively, compared to individuals with both PaCO(2)>28.1 mm Hg and CA activity <2...Continue Reading


Jul 1, 1976·The Journal of Clinical Investigation·R A GiammarcoB J Stinebaugh
Dec 1, 1990·Journal of Applied Physiology·T A Heming, A Bidani
Feb 1, 1988·Canadian Journal of Physiology and Pharmacology·T PiazzaJ P Mortola
Apr 1, 1985·Journal of Applied Physiology·M StäubliP W Straub
Jan 1, 1995·Annual Review of Biochemistry·W S Sly, P Y Hu
Jan 1, 1996·Annual Review of Physiology·R P Henry
Dec 25, 2002·Medicinal Research Reviews·Claudiu T SupuranAngela Casini
May 1, 1959·A.M.A. Archives of Neurology and Psychiatry·F PLUM, A G SWANSON
Nov 1, 1960·The Journal of Clinical Investigation·F C RECTORJ S SMITH
Dec 31, 2003·Lancet·Cynthia M Beall
Sep 28, 2004·European Journal of Applied Physiology·Tadayoshi MiyamotoKenji Sunagawa
Nov 27, 2004·Clinica Chimica Acta; International Journal of Clinical Chemistry·Wu-Hsien KuoShu-Chen Chu
Jan 21, 2006·The Journal of Experimental Biology·T GeorgalisK M Gilmour
May 9, 2006·Respiratory Physiology & Neurobiology·A J Esbaugh, B L Tufts
May 23, 2007·The Journal of Experimental Biology·K M GilmourS F Perry
Jan 3, 2008·Nature Reviews. Drug Discovery·Claudiu T Supuran


Dec 7, 2019·Journal of Sleep Research·Erik HoffJan Hedner
Apr 4, 2014·Clinical Chemistry and Laboratory Medicine : CCLM·Jia-Sin YangChiao-Wen Lin
Jun 25, 2020·International Journal of Molecular Sciences·Muhammad Sona KhanChitra D Mandyam

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