Elevated erythrocyte carbonic anhydrase activity is a novel clinical marker in hyperventilation syndrome

Clinical Chemistry and Laboratory Medicine : CCLM
Ying-Hock TengShun-Fa Yang

Abstract

The aim of this study was to evaluate the erythrocyte carbonic anhydrase (CA) activity in patients with hyperventilation syndrome. A total of 71 patients with hyperventilation syndrome and 60 controls were recruited in this study for measurement of the erythrocyte CA activity. CA activity was analyzed from erythrocyte using CA esterase activity analysis. The erythrocyte CA activity was significantly elevated in the patients with hyperventilation syndrome compared to controls (31.07+/-1.37 U/g Hb vs. 24.67+/-0.99 U/g Hb, p=0.003). The standardized beta value and significant R(2) value of total CA activity for prediction of hyperventilation was 0.155 (p=0.016) and 0.024, respectively. Moreover, a significant negative correlation was found between total CA activity and partial pressure of carbon dioxide (PaCO(2)) (r=-0.185, p=0.03, n=131). Furthermore, the adjusted odds ratios for patients with hyperventilation were 11.6 (95% CI: 4.8-27.9) and 51.0 (95% CI: 5.8-445.2) for individuals with either PaCO(2)<or=28.1 mm Hg or CA activity >or=29.71 U/g hemoglobin (Hb), and for individuals with both PaCO(2)<or=28.1 mm Hg and CA activity >or=29.71 U/g Hb, respectively, compared to individuals with both PaCO(2)>28.1 mm Hg and CA activity <2...Continue Reading

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Citations

Dec 7, 2019·Journal of Sleep Research·Erik HoffJan Hedner
Apr 4, 2014·Clinical Chemistry and Laboratory Medicine : CCLM·Jia-Sin YangChiao-Wen Lin
Jun 25, 2020·International Journal of Molecular Sciences·Muhammad Sona KhanChitra D Mandyam

Related Concepts

Carbonate Dehydratase
Erythrocytes
Hyperventilation
Viral Markers
Biological Markers
Carbon Dioxide
Carbonate Dehydratase
Erythrocytes
Hemoglobin
Psychogenic Hyperventilation

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