Elevated expression level of 60-kDa subunit of tRNA-guanine transglycosylase in colon cancer

Cancer Letters
Shunji IshiwataM Mizugaki

Abstract

tRNA-guanine transglycosylase (TGT) is an enzyme which synthesizes a modified nucleoside, queuosine, by exchanging the base moiety of guanosine for queuine in tRNA. We have reported that the expression level of the 60-kDa subunit of TGT (TGT60kD) is elevated in leukemic cells, however, there is no other report on the expression of TGT60kD in cancer cells. The expression levels of the TGT60kD protein are elevated in four of the five colon cancer cell lines and 83% of colon cancer tissues compared with normal tissues. The expression levels of the TGT60kD protein decreased in two colon cancer cell lines, after cell differentiation was induced. A marked positive staining of cancer cells in colon tissues was observed, and the subcellular staining pattern was mainly cytosolic. These data suggest that the role of TGT60kD in colon carcinogenesis.

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Citations

Apr 18, 2015·Nutrients·Claire FergusVincent P Kelly
Sep 24, 2015·Oncology Reports·Gang HuangWeiping Zhou
May 7, 2014·Biochimica Et Biophysica Acta·Catherine D EichhornJuli Feigon
Jun 30, 2012·Angewandte Chemie·Thomas CarellMirko Wagner
Jan 29, 2020·Cancer Letters·Rosaura Esteve-PuigManel Esteller

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