Elevated expression of activated TH 2 cells and milk-specific TH 2 cells in milk-induced eosinophilic esophagitis

Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
Antonella CianferoniJonathan M Spergel

Abstract

Eosinophilic esophagitis (EoE) is an allergic inflammatory disease that is triggered by food allergens and characterized by progressive esophageal dysfunction. Esophageal biopsy specimens are characterized by eosinophilia and expression of TH2 cytokines. To ascertain whether TH2 cells can exist in the peripheral blood in patients with milk-induced EoE. Peripheral blood mononuclear cells from 20 children with milk-induced EoE were collected during active EoE (EoE-A) while consuming milk and inactive EoE (EoE-I) while not consuming milk, and 8 healthy patients without EoE were used as controls. The samples were analyzed for T-cell phenotype, including intracellular cytokines before and after incubation with milk antigens and assessed by flow cytometry. We found a significant increase in CD4+ TH2 cells in the peripheral blood of patients with EoE-A compared with the controls. Furthermore, we observed a significant mean (SD) increase in the activation marker of CD154+ T cells (0.17% [0.047%]) in patients with EoE-A compared with control patients (0.034% [0.007%]) and EoE-I (0.025% [0.008]). These CD4+ T cells expressed significantly increase levels of TH2 cytokines (interleukins 4, 5, and 13) compared with the EoE-I and control gro...Continue Reading

Citations

Sep 14, 2018·American Journal of Physiology. Gastrointestinal and Liver Physiology·Eisuke InageJoanne C Masterson
Nov 6, 2018·Expert Review of Clinical Immunology·Melanie A RuffnerAntonella Cianferoni
Feb 5, 2019·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Antonella CianferoniJonathan M Spergel
Dec 4, 2019·Clinical and Translational Gastroenterology·Evan S DellonMichael Kulis
Mar 13, 2020·Expert Review of Clinical Immunology·Salvatore OlivaMarc E Rothenberg
Feb 6, 2020·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Hamish PhilpottEvan S Dellon
Mar 25, 2019·Clinical Reviews in Allergy & Immunology·Peter Capucilli, David A Hill
Nov 22, 2019·Current Gastroenterology Reports·Prerana Williamson, Seema Aceves
Jun 10, 2020·JGH Open : an Open Access Journal of Gastroenterology and Hepatology·Fumiaki IshibashiRyu Tanaka
Dec 29, 2020·Journal of Asthma and Allergy·Jeffrey M WilsonEmily C McGowan
Feb 10, 2021·The Journal of Immunology : Official Journal of the American Association of Immunologists·Melanie A RuffnerKaren Cerosaletti
Jun 2, 2021·Current Opinion in Gastroenterology·Wonhee Woo, Seema S Aceves

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