PMID: 9180153May 29, 1997Paper

Elevated expression of calcium-binding protein p9Ka is associated with increasing malignant characteristics of rat prostate carcinoma cells

International Journal of Cancer. Journal International Du Cancer
Y KeC S Foster

Abstract

Northern and Western blotting techniques were used to study expression of the mRNA and corresponding protein product of the S100-related calcium-binding molecule p9Ka in 6 different metastatic cell lines of the Dunning R3327 rat prostate cancer model. In cells with the lowest metastatic capability (G cells), p9Ka mRNA was barely detectable. In 2 weakly metastatic cell lines (AT-1 and AT-2), p9Ka transcript amounts were, respectively, 6.29 +/- 0.74 and 5.55 +/- 1.11 times that detected in the G cells. In 3 highly metastatic cell lines (AT-3, MAT-LyLu and MAT-Lu), the amounts of p9Ka mRNA were, respectively, 12.85 +/- 2.82, 13.06 +/- 1.69 and 11.62 +/- 1.81 times that expressed in the G cells. Western blot analyses detected no p9Ka protein in the G cells. The amounts of p9Ka protein expressed by tumour cells of intermediate metastatic capability (AT-1 and AT-2) were 3.4 +/- 1.3 microg and 3.3 +/- 1.4 microg, respectively, per 1 x 10(6) cells. The amounts of p9Ka protein expressed by the tumour cells of highest metastatic capability (AT-3, MAT-LyLu and MAT-Lu) were 8.3 +/- 1.1 microg, 8.7 +/- 1.6 microg and 9.6 +/- 1.7 microg, respectively, per 1 x 10(6) cells. Our data reveal a direct association between the elevated expression o...Continue Reading

References

Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·J C AlwineG R Stark
Apr 25, 1977·Biochimica Et Biophysica Acta·J T Russell, N A Thorn
Jun 13, 1992·Lancet·I R Hart, A Saini
Jun 15, 1990·Biochemical and Biophysical Research Communications·R BarracloughP S Rudland
Feb 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·P Masiakowski, E M Shooter
Aug 25, 1987·Nucleic Acids Research·L L Jackson-GrusbyD I Linzer
Jun 23, 1986·FEBS Letters·R KuwanoY Takahashi
Jun 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·H Aviv, P Leder
Jan 1, 1982·International Review of Cytology·L J Van EldikD M Watterson
Jan 1, 1994·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R Barraclough, P S Rudland
Jun 1, 1994·International Journal of Cancer. Journal International Du Cancer·M PedrocchiC W Heizmann

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Citations

Sep 23, 2006·Proceedings of the National Academy of Sciences of the United States of America·Mohammad SaleemHasan Mukhtar
Jul 31, 2002·Molecular Pathology : MP·C L LiB Perbal
Aug 23, 2008·Breast Cancer Research : BCR·Yvonne RadestockSabine Hombach-Klonisch
Jan 23, 1999·The American Journal of Pathology·P CornfordC S Foster
Jan 26, 2005·Human Pathology·Ishtiaq RehmanFreddie C Hamdy
Nov 23, 2005·The International Journal of Biochemistry & Cell Biology·Y DingM B A Djamgoz
Apr 13, 2002·Toxicologic Pathology·Abraham NyskaRobert R Maronpot
Jun 29, 2000·Medical Oncology·S N PentyalaS A Khan
Dec 7, 2005·International Journal of Cancer. Journal International Du Cancer·Shiva S ForootanYouqiang Ke
Oct 27, 2017·Oncotarget·Fei FeiShiwu Zhang
May 8, 1999·BJU International·C S FosterY Ke
Jan 6, 2001·Scandinavian Journal of Urology and Nephrology. Supplementum·C S FosterW A Sakr

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