Elevated expression of chloride intracellular channel 1 is correlated with poor prognosis in human gliomas.

Journal of Experimental & Clinical Cancer Research : CR
Liang WangGuodong Gao

Abstract

Chloride intracellular channel 1 (CLIC1) is expressed ubiquitously in human tissues and is involved in the regulation of cell cycle, cell proliferation and differentiation. Recent studies have shown that CLIC1 is highly expressed in several human malignant tumors. However, its roles in human gliomas are still unclear. The aim of this study was to investigate the clinicopathological significance and prognostic value of CLIC1 expression in human gliomas. CLIC1 expression in human gliomas and nonneoplastic brain tissues was measured by real-time quantitative RT-PCR assay and immunohistochemistry. Its association with clinicopathological factors or prognosis in patients with gliomas was statistically analyzed. The expression of CLIC1 at both mRNA and protein levels was significantly increased in high-grade (Grade III~IV) glioma tissues compared with that in low-grade (Grade I~II) and nonneoplastic brain tissues, and was up-regulated with ascending tumor World Health Organization (WHO) grades. The elevated expression of CLIC1 protein was also significantly correlated with low Karnofsky performance score (KPS) (P=0.008). Moreover, both univariate and multivariate analysis shown that high CLIC1 expression was significantly associated ...Continue Reading

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Citations

Oct 12, 2013·Journal of the National Cancer Institute·Matteo SettiGiuliana Pelicci
Apr 9, 2015·Journal of Neuropathology and Experimental Neurology·Duthika M MallawaaratchyKimberley L Kaufman
Apr 19, 2013·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Sheng ZhangPing-Guo Liu
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Jun 18, 2021·Frontiers in Immunology·Stoyan Tankov, Paul R Walker

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Methods Mentioned

BETA
PCR
surgical resection

Software Mentioned

SPSS

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