Elevated expression of CST1 promotes breast cancer progression and predicts a poor prognosis

Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte
Da-Nian DaiWei-Dong Wei

Abstract

Cystatin SN (CST1) belongs to the type 2 cystatin (CST) superfamily, which restricts the proteolytic activities of cysteine proteases. CST1 has been recently considered to be involved in the development of several human cancers. However, the prognostic significance and function of CST1 in breast cancer remains unknown. In the current study, we found that CST1 was generally upregulated in breast cancer at both mRNA and protein level. Furthermore, overall survival (OS) and disease-free survival (DFS) in the low CST1 expression subgroup were significantly superior to the high CST1 expression subgroup (OS, p < 0.001; DFS, p < 0.001), which indicated that CST1 expression level was closely correlated to the survival risk of these patients. Univariate and multivariate analyses demonstrated that CST1 expression was an independent prognostic factor, the same as ER status and nodal status. Next, CST1 overexpression promoted breast cancer cell proliferation, clonogenicity, migration, and invasion abilities. By contrast, knockdown of CST1 attenuated these malignant characteristics in breast cancer cells. Collectively, our study indicates that CST1 cannot only serve as a significant prognostic indicator but also as a potential therapeutic t...Continue Reading

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Citations

May 4, 2018·Molecular Carcinogenesis·Rishi K JaiswalPramod K Yadava
Oct 16, 2018·Journal of Cellular and Molecular Medicine·Jinlian SongLin Hou
Jan 11, 2019·Journal of Cellular Physiology·Youyi XiongXinguang Qiu
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Dec 19, 2019·Frontiers in Genetics·Jie LiYadong Wang
Sep 18, 2020·Science Translational Medicine·Sonia García-CalzónCharlotte Ling
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Apr 4, 2019·BMC Genomics·Alberto Berral-GonzalezGuillermo Ayala
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May 25, 2020·Molecular Cell·Shwu-Yuan WuCheng-Ming Chiang
May 11, 2021·Frontiers in Cell and Developmental Biology·Yang LiuShaoyan Liu
Jul 16, 2021·Journal of Computational Biology : a Journal of Computational Molecular Cell Biology·Bruno César FeltesMárcio Dorn

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Methods Mentioned

BETA
surgical resection
PCR
Protein Assay
electrophoresis
transfection

Software Mentioned

Oncomine
MultiExperiment Viewer
SPSS
ImageJ

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