Elevated expression of inducible nitric oxide synthase and inflammatory cytokines in the alveolar macrophages after esophagectomy

Critical Care Medicine
Kunihiko KooguchiSatoru Hashimoto

Abstract

To evaluate the role of inducible nitric oxide (NO) synthase (iNOS) and inflammatory cytokines in alveolar macrophages (AMs) after esophagectomy in the pathogenesis of acute lung injury. Prospective, exploratory, open-labeled clinical study. Intensive care unit and operating room in a university hospital. Thirteen patients receiving esophagectomy with carcinoma of the esophagus (postesophagectomy group), ten patients just before the surgery (preoperation group), and seven patents receiving surgery less invasive than esophagectomy (other surgery group) were selected. Bronchoalveolar lavage fluid (BALF) and blood samples were obtained from study groups. The AMs in the BALF collected from each group were stained immunohistochemically with antibodies against iNOS, interleukin (IL)-6, and IL-8. The intensities of these expressions were determined by semiquantitative cytofluorometric system. NOx (NO2- + NO3-), IL-6, and IL-8 levels in the BALF and plasma were measured concurrently. The expressional intensities of iNOS, IL-6, and IL-8 in AMs obtained from the postesophagectomy group were maximal 24 hrs after the skin incision and significantly more evident than those from other groups. The IL-6, IL-8, and NOx levels in BALF and IL-6 a...Continue Reading

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Citations

Feb 3, 2007·Annales Françaises D'anesthèsie Et De Rèanimation·P MicheletJ-P Auffray
Oct 21, 2014·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·P R BoshierG B Hanna
Oct 24, 2012·Anesthesiology Clinics·J Michael JaegerRandal S Blank
Mar 5, 2016·Journal of Surgical Oncology·Tatsuto NishigoriYoshiharu Sakai
May 6, 2008·Anesthesiology Clinics·Ju-Mei Ng
Aug 19, 2008·The Journal of Surgical Research·Jon A TsaiKristina Nilsson-Ekdahl
Mar 17, 2004·Pediatric Pulmonology·Jamie L WooldridgeFrank J Accurso
Sep 1, 2007·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·U ZinggA Zollinger
Jan 17, 2008·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·M MoritaY Maehara
Nov 1, 2005·Vascular Pharmacology·Sanjay Mehta
Feb 20, 2015·Journal of Cancer Research and Therapeutics·Wei-Chun WuAizemaiti Rusidanmu
Jun 25, 2003·British Journal of Anaesthesia·S V Baudouin
Oct 17, 2017·Journal of Breath Research·Piers R BoshierNandor Marczin
Jul 19, 2008·Seminars in Cardiothoracic and Vascular Anesthesia·Francis Theodore Lytle, Daniel R Brown
Nov 26, 2010·Current Opinion in Anaesthesiology·Ju-Mei Ng
Mar 1, 2013·Journal of Breath Research·Piers R BoshierNandor Marczin

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