Elevated expression of phosphorylated c-Jun NH2-terminal kinase in basal-like and "triple-negative" breast cancers

Human Pathology
Xiao WangGengyin Zhou

Abstract

Basal-like carcinomas and human epidermal growth factor receptor 2 (HER-2/neu) overexpression carcinomas are the subgroups of breast cancers that have the most aggressive clinical behavior. Phosphorylation/activation of c-Jun NH2-terminal kinase is characterized as a stress-activated protein kinase, which regulates apoptosis after cellular stress. The aim of this study was to evaluate the association of phosphorylated c-Jun NH2-terminal kinase expression with phenotypes and clinicopathologic parameters of breast cancer. Phosphorylated c-Jun NH2-terminal kinase was immunohistochemically measured in a cohort of 160 patients with invasive breast cancer treated with therapeutic surgery followed by anthracycline or docetaxel-based chemotherapy. These results were further correlated with the phenotypes and clinicopathologic characteristics of breast cancers. Increased phosphorylated c-Jun NH2-terminal kinase expression was significantly associated with lack of estrogen receptor expression (P < .0001), positivity for cytokeratins 5/6 (P = .029), epidermal growth factor receptor (P = .035), basal-like phenotype (P = .015), and "triple-negative" phenotype (P = .01). Furthermore, the positive expression of phosphorylated c-Jun NH2-termin...Continue Reading

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Citations

Jan 1, 2010·Cancers·Jennifer R Choo, Torsten O Nielsen
Mar 2, 2011·The Journal of Biological Chemistry·Shreya MitraCarla Lynn Van den Berg
Jan 30, 2013·Molecular Carcinogenesis·Xu QinXiaomei Lu
Dec 21, 2017·Functional & Integrative Genomics·Ramireddy Sriroopreddy, C Sudandiradoss
Jun 25, 2019·Frontiers in Endocrinology·Miaolong LuXianquan Zhan
Sep 5, 2020·Cancers·Xiaoping WangNaoto T Ueno
Sep 29, 2019·European Journal of Medicinal Chemistry·Igor A SchepetkinMark T Quinn

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