Elevated expression of the tumor suppressing protein p53 is associated with the presence of mouse mammary tumor-like env gene sequences (MMTV-like) in human breast cancer

Breast Cancer Research and Treatment
J S LawsonW D Rawlinson

Abstract

Mouse mammary tumor virus (MMTV) has a proven role in breast carcinogenesis in wild mice and genetically susceptible laboratory inbred mice. The carcinogenic characteristics of this virus are enhanced by estrogen and other steroid hormones. MMTV-like envelope gene sequences, with 95% homology to MMTV have been identified in approximately 40% of breast cancers in US, Australian and Argentinian women. The presence of such sequences indicates the presence of a replication competent MMTV-like virus in human breast tumors. Whether an MMTV-like virus contributes to human breast cancer remains to be demonstrated. Non-statistically significant differences in p53 expression between MMTV-like positive and negative human breast cancers have previously been observed. As high p53 protein expression is associated with aggressive breast carcinogenesis we sought to determine if there were associations between the presence of MMTV-like gene sequences and elevated p53 expression in both invasive ductal carcinomas (IDC) and ductal carcinomas in situ (DCIS). We also investigated the expression of other biomarkers which are commonly associated with human breast cancer. These included estrogen receptor, progesterone receptor, Ki67, Cyclin D1, Bcl-2 ...Continue Reading

References

Mar 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·R Mesa-TejadaS Spiegelman
Nov 1, 1991·The Journal of Pathology·R A WalkerJ M Varley
Feb 26, 1971·Nature·D H MooreA B Vaidya
Jan 1, 1981·The Journal of Clinical Investigation·S S WitkinN K Day
Apr 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·N K DayR A Good
Sep 10, 1998·Journal of the National Cancer Institute·T E RohanR A Kandel
Sep 11, 1999·Breast Cancer Research and Treatment·S MénardM I Colnaghi
Mar 27, 2001·Archives of Virology·Y WangB G Pogo

❮ Previous
Next ❯

Citations

Jan 26, 2012·Breast Cancer Research and Treatment·Deepti Joshi, Gertrude Case Buehring
May 20, 2006·The Journal of Pathology·F ZammarchiG Bevilacqua
Apr 27, 2010·Journal of Medical Virology·Harpreet JohalWilliam D Rawlinson
Mar 7, 2006·Medical Hypotheses·B LaumbacherR Wank
Jan 1, 2010·Herpesviridae·Lualhati E HarkinsCharles S Cobbs
Apr 7, 2004·Cancer Genetics and Cytogenetics·Avery A Sandberg
Apr 17, 2007·Advances in Cancer Research·Robert D Cardiff, Nicholas Kenney
Jun 29, 2010·Gastroentérologie Clinique Et Biologique·A L Mason, G Zhang
Jun 28, 2021·Infectious Agents and Cancer·Fa-Liang WangHong-Chuan Jin

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Breast Cancer: Chemo-Resistance

Some cancers are difficult to treat and aggressive including the "triple-negative" breast cancer. This type of cancer is chemoresistant even before chemotherapy begins. Here are the latest discoveries chemo-resistance in breast cancer.

Carcinoma, Ductal

Ductal carcinoma is a malignant neoplasm involving the ductal systems of any of a number of organs, such as the mammary glands, pancreas, prostate or lacrimal gland. Discover the latest research on ductal carcinoma here.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.

Related Papers

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
C E FordW D Rawlinson
International Journal of Cancer. Journal International Du Cancer
Rachel ZangenDavid Sidransky
© 2021 Meta ULC. All rights reserved