Abstract
Mouse mammary tumor virus (MMTV) has a proven role in breast carcinogenesis in wild mice and genetically susceptible laboratory inbred mice. The carcinogenic characteristics of this virus are enhanced by estrogen and other steroid hormones. MMTV-like envelope gene sequences, with 95% homology to MMTV have been identified in approximately 40% of breast cancers in US, Australian and Argentinian women. The presence of such sequences indicates the presence of a replication competent MMTV-like virus in human breast tumors. Whether an MMTV-like virus contributes to human breast cancer remains to be demonstrated. Non-statistically significant differences in p53 expression between MMTV-like positive and negative human breast cancers have previously been observed. As high p53 protein expression is associated with aggressive breast carcinogenesis we sought to determine if there were associations between the presence of MMTV-like gene sequences and elevated p53 expression in both invasive ductal carcinomas (IDC) and ductal carcinomas in situ (DCIS). We also investigated the expression of other biomarkers which are commonly associated with human breast cancer. These included estrogen receptor, progesterone receptor, Ki67, Cyclin D1, Bcl-2 ...Continue Reading
References
Mar 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·R Mesa-TejadaS Spiegelman
Nov 1, 1991·The Journal of Pathology·R A WalkerJ M Varley
Mar 1, 1992·Cancer·M E BurR Lew
Apr 18, 1985·Nature·M MowatS Benchimol
Feb 26, 1971·Nature·D H MooreA B Vaidya
Jan 1, 1981·The Journal of Clinical Investigation·S S WitkinN K Day
Apr 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·N K DayR A Good
Sep 10, 1998·Journal of the National Cancer Institute·T E RohanR A Kandel
Sep 11, 1999·Breast Cancer Research and Treatment·S MénardM I Colnaghi
Nov 30, 1999·Lancet·J S LawsonD Trichopoulos
Mar 14, 2000·Oncogene·R Callahan, G H Smith
Mar 27, 2001·Archives of Virology·Y WangB G Pogo
Citations
Jan 26, 2012·Breast Cancer Research and Treatment·Deepti Joshi, Gertrude Case Buehring
Jul 22, 2008·Cancer Letters·M HachanaS Korbi
May 20, 2006·The Journal of Pathology·F ZammarchiG Bevilacqua
Apr 27, 2010·Journal of Medical Virology·Harpreet JohalWilliam D Rawlinson
Mar 7, 2006·Medical Hypotheses·B LaumbacherR Wank
Jan 27, 2009·Journal of Hepatology·Harpreet JohalWilliam D Rawlinson
Jan 1, 2010·Herpesviridae·Lualhati E HarkinsCharles S Cobbs
Nov 28, 2012·PloS One·Wendy K GlennJames S Lawson
Oct 11, 2012·PloS One·Nicholas C D'AmatoVictoria L Seewaldt
May 17, 2012·PloS One·Matthew D WilkersonD Neil Hayes
Apr 7, 2004·Cancer Genetics and Cytogenetics·Avery A Sandberg
May 6, 2008·Clinics in Liver Disease·Andrew L Mason, Shawn T Wasilenko
Apr 17, 2007·Advances in Cancer Research·Robert D Cardiff, Nicholas Kenney
Jun 29, 2010·Gastroentérologie Clinique Et Biologique·A L Mason, G Zhang
Jun 28, 2021·Infectious Agents and Cancer·Fa-Liang WangHong-Chuan Jin