PMID: 9535106Apr 16, 1998Paper

Elevated extracellular glutamate concentrations increased malondialdehyde production in anesthetized rat brain cortex

Neuroscience Letters
C S YangJ S Kuo

Abstract

Oxidative stress is believed to be involved in the damaging mechanism of excitotoxic insult. Thus, we investigated the effect of elevated extracellular glutamate levels on malondialdehyde production, a common index of lipid peroxidation, in anesthetized rat brain cortex. Elevation of extracellular glutamate levels was achieved either by exogenously perfusing glutamate solutions, or by perfusing L-trans-pyrrolidine-2,4-dicarboxylate (PDC), a competitive inhibitor of glutamate uptake transporter, through an implanted microdialysis probe. Malondialdehyde levels in the microdialysates, which were reacted with thiobarbituric acid, were analyzed by a high performance liquid chromatography system equipped with a fluorescence detector. Perfusion of glutamate (1.5 and 15 mM) resulted in dose-dependent increases in extracellular malondialdehyde production (as high as a 6-fold increase in malondialdehyde production following perfusion of 15 mM glutamate solution). PDC (3.14 and 31.4 mM), not only significantly increased the extracellular glutamate levels in a dose-dependent manner, but also dramatically increased malondialdehyde production (as high as 20-fold increase). These results suggest that excitotoxicity induces oxidative stress in...Continue Reading

References

Sep 1, 1990·Trends in Pharmacological Sciences·B Meldrum, J Garthwaite
Mar 3, 1994·The New England Journal of Medicine·S A Lipton, P A Rosenberg
May 23, 1994·European Journal of Pharmacology·C ItoM Kunihara
Nov 10, 1995·Neuroscience Letters·A H WaterfallC A Marsden
Mar 11, 1996·Brain Research·A H WaterfallC A Marsden

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Citations

Nov 24, 1999·Drugs in R&D
Jul 21, 2004·Brain Research·Laurence M KatzKyunam Park
Dec 27, 2005·Brain Research Bulletin·A JelenkovićZ Prolić
Jan 26, 2020·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Morad BornavardAlireza Atashpanjeh

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