Elevated fluid shear stress enhances postocclusive collateral artery growth and gene expression in the pig hind limb

Arteriosclerosis, Thrombosis, and Vascular Biology
Frederic PippThomas Schmitz-Rixen

Abstract

The role of fluid shear stress (FSS) in collateral vessel growth remains disputed and prospective in vivo experiments to test its morphogenic power are rare. Therefore, we studied the influence of FSS on arteriogenesis in a new model with extremely high levels of collateral flow and FSS in pig and rabbit hind limbs. A side-to-side anastomosis was created between the distal stump of one of the bilaterally occluded femoral arteries with the accompanying vein. This clamps the collateral reentry pressure at venous levels and increases collateral flow, which is directed to a large part into the venous system. This decreases circumferential wall stress and markedly increases FSS. One week after anastomosis, angiographic number and size of collaterals were significantly increased. Maximal collateral flow exceeded by 2.3-fold that obtained in the ligature-only hind limb. Capillary density increased in lower leg muscles. Immunohistochemistry revealed augmented proliferative activity of endothelial and smooth muscle cells. Intercellular adhesion molecule-1 and vascular cell adhesion molecule (VCAM)-1 were upregulated, and monocyte invasion was markedly increased. In 2-dimensional gels, actin-regulating cofilin1 and cofilin2, destrin, and...Continue Reading

References

Mar 1, 1987·Journal of Vascular Surgery·C K ZarinsS Glagov
Jan 1, 1967·Cardiologia : bollettino della Società italiana di cardiologia·W SchaperR Xhonneux
Jan 1, 1993·Journal of Cardiovascular Pharmacology·B L Langille
Oct 10, 1997·The American Journal of Physiology·W D ItoW Schaper
Feb 13, 2001·Cardiovascular Research·I E HoeferW Schaper
May 8, 2002·Circulation·Toshiro MatsunagaWilliam M Chilian
May 11, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Annemiek J M CornelissenJos A E Spaan
Jul 9, 2002·Journal of Molecular and Cellular Cardiology·Dimitri ScholzWolfgang Schaper
Jan 1, 2003·Biochemical and Biophysical Research Communications·Kerstin BoenglerElisabeth Deindl
May 7, 2003·Cell·Francesc MirallesRichard Treisman
May 7, 2003·Progress in Biophysics and Molecular Biology·Nitzan ResnickEfrat Wofovitz
Jul 2, 2003·Circulation·Daniel G SeddingRuediger C Braun-Dullaeus
Sep 17, 2003·Cardiovascular Drugs and Therapy·Michael Schwemmer, Eberhard Bassenge

❮ Previous
Next ❯

Citations

Dec 23, 2008·Basic Research in Cardiology·Wolfgang Schaper
Feb 18, 2006·Cell and Tissue Research·Dimitri Scholz, Wolfgang Schaper
Dec 31, 2005·Cardiovascular Drugs and Therapy·Wolfgang Schaper
May 7, 2009·Antioxidants & Redox Signaling·June YunWilliam M Chilian
May 25, 2005·Stem Cells and Development·Nicanor I Moldovan
Jun 26, 2009·Tissue Engineering. Part B, Reviews·Matthias W LaschkeMichael D Menger
Sep 15, 2012·Cardiovascular Research·Yang Chul BöringJürgen Schrader
Apr 13, 2013·Cardiovascular Research·Imo E HoeferMat J A P Daemen
Oct 25, 2011·European Heart Journal·W Schaper
Feb 23, 2010·Journal of Cardiovascular Pharmacology·Kerstin TroidlWolfgang Schaper
Apr 21, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Ryan ReedPetra Rocic
Jul 30, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·Roberto HodaraW Robert Taylor
Oct 12, 2010·Circulation Research·Zhongming ChenEllie Tzima
Jun 6, 2013·BMC Medicine·Pascal MeierChristian Seiler
Dec 25, 2008·Regenerative Medicine·Edward A Phelps, Andres J Garcia
May 21, 2015·International Journal of Molecular Sciences·Smriti Murali KrishnaJonathan Golledge
Dec 31, 2015·Antioxidants & Redox Signaling·Arif Yurdagul, A Wayne Orr
Jan 15, 2009·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Wilma SchierlingThomas Schmitz-Rixen
Sep 4, 2007·European Journal of Clinical Investigation·S GrundmannI E Hoefer
Sep 24, 2015·The Journal of Cell Biology·Ine VandersmissenAernout Luttun
Jun 16, 2010·Clinical Science·Matthijs S RuiterMaya S Huijberts
Jul 18, 2008·Diabetes·Jolanda M van GoldeMaya S Huijberts
Jul 29, 2015·Acta Biomaterialia·Young Hwan ChoiNathaniel S Hwang
Apr 21, 2007·European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology·Rainer ZbindenChristian Seiler
Jan 1, 2010·Therapeutic Advances in Cardiovascular Disease·Catharina NesselmannGustav Steinhoff
Aug 31, 2018·International Journal of Molecular Sciences·Ludwig T WeckbachElisabeth Deindl
Aug 26, 2006·Circulation Research·Inka EitenmüllerWolfgang Schaper
Jun 1, 2013·Journal of the American Heart Association·Jill J WeyersWilliam M Mahoney
May 9, 2015·Circulation Research·Michael Simons, Anne Eichmann
Jan 7, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·Armin HelischWolfgang Schaper
Sep 26, 2009·Arteriosclerosis, Thrombosis, and Vascular Biology·Kerstin TroidlChristian Troidl
Jul 31, 2013·Circulation Research·Filipa MoraesMichael Simons

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Arteriosclerosis, Thrombosis, and Vascular Biology
Kerstin TroidlChristian Troidl
Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
Wilma SchierlingThomas Schmitz-Rixen
© 2022 Meta ULC. All rights reserved