Elevated free IGF2 levels in localized, early-stage breast cancer in women

European Journal of Endocrinology
Ulrick EspelundAllan Flyvbjerg

Abstract

Epidemiological studies imply an association between circulating IGF1 and breast cancer, whereas the role of IGF2, which also acts on the IGF1 receptor, is less settled. This study investigates the association between IGF2 and breast cancer in patients with localized disease. The participants were women with well-characterized, early stage, localized breast cancer (n=43) and matched healthy women (n=38), from whom fasting serum levels of IGF-related peptides were measured. In patients, mean free IGF2 was increased (+57%, P<0.001), in spite of reduced total IGF2 levels (-12%, P=0.003) when compared with controls. Similar changes were seen in free IGF1 (+28%, P=0.004) and total IGF1 (-16% P=NS). Pro-IGF2 and IGF-binding protein 1 (IGFBP1) were unchanged. IGFBP2 was reduced by 22% in the patients (P=0.004). The patients showed reduced IGFBP3 protease activity and accordingly increased levels of intact IGFBP3, whereas total IGFBP3 was unchanged. Women with localized, early-stage breast cancer show elevated circulating free IGF1 and IGF2, reduced total IGF2 and alterations in IGFBPs. The changes observed despite minimal cancer disease suggest a role for the circulating IGF system in the progression of breast cancer in women.

Citations

Jan 23, 2013·Breast Cancer Research and Treatment·Sarah Q ToColin D Clyne
Oct 25, 2013·Journal of Mammary Gland Biology and Neoplasia·Valentina BelardiDerek LeRoith
Jun 29, 2011·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Susan L NeuhausenDaniel L Gillen
Oct 2, 2013·Endocrine-related Cancer·Callum Livingstone
Nov 6, 2013·Biochimica Et Biophysica Acta·Yousef HawsawiJames Beattie
Aug 19, 2015·Molecular and Cellular Endocrinology·Daniel H Bedinger, Sean H Adams
Dec 22, 2004·Progress in Neuro-psychopharmacology & Biological Psychiatry·Michiko NakazatoMasaomi Iyo
Mar 9, 2012·Breast Cancer : Basic and Clinical Research·Roshni RaoDavid Euhus
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