Elevated growth differentiation factor 15 expression predicts poor prognosis in epithelial ovarian cancer patients

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Ying ZhangJian Wang

Abstract

The purpose of this study was to determine the expression of growth differentiation factor 15 (GDF15) and explore its clinical significance in epithelial ovarian cancer (EOC) patients. The expression of GDF15 in EOC tissues and serum samples was evaluated using immunohistochemistry and enzyme-linked immunosorbent assay (ELISA), respectively. The association of GDF15 expression with clinicopathologic parameters was analyzed. Survival time was assessed using the Kaplan-Meier technique and Cox regression model. Both in EOC tissues and serum, high GDF15 levels were obviously related with advanced International Federation of Gynecology and Obstetrics (FIGO) stage, lymph node metastasis, ascites, and chemoresistance. Kaplan-Meier analysis indicated that EOC patients with high GDF15 expression showed poorer progression-free survival (PFS) and overall survival (OS). Multivariate analysis demonstrated that GDF15 expression was an independent predictor of PFS in EOC patients. Our study shows that elevated GDF15 expression was associated with poor prognosis in EOC patients. We suggest that GDF15 is a novel biomarker for the early detection of EOC, prediction of the response to chemotherapy, and screening for recurrence in EOC patients.

References

Apr 10, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jens KoopmannMichael Goggins
Sep 22, 2005·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·M J DuffyM Zwirner
Feb 18, 2006·Circulation Research·Tetsuro Ago, Junichi Sadoshima
Nov 30, 2006·Journal of Biochemistry and Molecular Biology·Thomas E ElingChang Ho Lee
May 13, 2008·American Journal of Obstetrics and Gynecology·Vladimir NossovRobin Farias-Eisner
Jun 13, 2009·International Journal of Cancer. Journal International Du Cancer·Sophie ShnaperMonika E Hegi
Apr 7, 2010·Nature Reviews. Clinical Oncology·Amer K Karam, Beth Y Karlan
Jun 26, 2010·Gynecologic Oncology·Anne Cathrine StaffBen Davidson
Aug 7, 2010·Methods in Molecular Biology·Ronald SimonGuido Sauter
Feb 8, 2011·CA: a Cancer Journal for Clinicians·Ahmedin JemalDavid Forman
Sep 7, 2011·Cancer Prevention Research·Oliver Dorigo, Jonathan S Berek
Sep 24, 2011·Nature Reviews. Cancer·Sebastian VaughanFrances R Balkwill
Jan 17, 2012·Cancer Letters·Brian S Gloss, Goli Samimi
Feb 22, 2012·Clinical Obstetrics and Gynecology·John R van Nagell, Edward John Pavlik
Dec 12, 2012·Biochemical Pharmacology·Xingya WangThomas E Eling
Dec 19, 2013·Experimental and Therapeutic Medicine·Gongli YangChunhui Wang
Jan 9, 2014·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Feb 26, 2014·Journal of the National Cancer Institute·Raaj S MehtaAndrew T Chan
Mar 29, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C Z YangL P Zhong
Jun 1, 2014·Gynecologic Oncology·David G Mutch, Jaime Prat
Jun 3, 2014·Molecular Cancer·Mildred FelderManish S Patankar
Jun 21, 2014·Future Oncology·Moisés Blanco-CalvoManuel Valladares-Ayerbes
Sep 17, 2014·World Journal of Biological Chemistry·Joshua G CohenRobin Farias-Eisner
Feb 27, 2015·Rambam Maimonides Medical Journal·Joseph MenczerTally Levy

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Citations

Jul 31, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Zhai ErtaoCai Shirong
Jun 24, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Hai-Xia LiuBi-Liang Chen
Apr 20, 2018·Journal of Neuro-oncology·Mirella BaroniCarlos Alberto Scrideli
Nov 7, 2019·Growth Factors·Anupama ModiSanjeev Misra
Dec 28, 2018·Biological Reviews of the Cambridge Philosophical Society·Paul R KempMichael I Polkey
Jun 9, 2020·Frontiers in Immunology·Jörg WischhusenWolf Herman Fridman
Oct 14, 2017·Molecular Cancer Research : MCR·Balabhadrapatruni V S K ChakravarthiSooryanarayana Varambally
Jan 25, 2021·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Zheng ZhangLi-Qiang Qin

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