Apr 8, 2017

Elevated heparanase expression is associated with poor prognosis in breast cancer: a study based on systematic review and TCGA data

Oncotarget
Xu SunJin-Ping Li

Abstract

Heparanase promotes tumorigenesis, angiogenesis, and metastasis. Here, we conducted a study based on systematic review and the Cancer Genome Atlas (TCGA) data that examined heparanase expression in clinical samples to determine its prognostic value. According to the meta-analysis and TCGA data, we found that heparanase expression was up-regulated in most breast cancer specimens, and elevated heparanase expression was associated with increased lymph node metastasis, larger tumor size, higher histological grade, and poor survival. These results suggest that targeting heparanase might improve treatments for breast cancer patients.

Mentioned in this Paper

Study
Gene Expression Regulation, Neoplastic
The Cancer Genome Atlas
Meta-Analysis (Publications)
Meta Analysis (Statistical Procedure)
TNM Staging System
Genome
Angiogenic Process
Hpse protein, rat
Neoplasms

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