Elevated HERV-K Expression in Soft Tissue Sarcoma Is Associated with Worsened Relapse-Free Survival

Frontiers in Microbiology
Maria GieblerThomas Greither

Abstract

A wide variety of endogenous retroviral sequences has been demonstrated in the human genome so far, divided into several different families according to the sequence homology to viral strains. While increased expression of human endogenous retrovirus (HERV) elements has already been linked to unfavorable prognosis in hepatocellular carcinoma, breast cancer, and ovarian carcinoma yet less is known about the impact of the expression of different HERV elements on sarcomagenesis in general as well as the outcome of soft tissue sarcoma (STS) patients. Therefore, in this study the association between expression of HERV-K and HERV-F and the clinicopathological characteristics in a cohort of STSs as well as the patients' prognosis was evaluated. HERV-K and HERV-F expression was assessed by quantitative real-time PCR in 120 patient specimens. HERV-K and HERV-F expression was significantly correlated (rS= 0.5;p= 6.4 × 10-9; Spearman's rank bivariate correlation). Also, tumor diameter exhibited a significant negative association to HERV-K and HERV-F expression. Levels of several hypoxia-related RNAs like HIF-1α and miR-210 showed a significant positive correlation with both HERV-K and HERV-F expression. Although in survival analyses no im...Continue Reading

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Citations

Jan 8, 2019·Reviews in Medical Virology·Mengwen ZhangShu Zheng
Aug 1, 2020·Reviews in Medical Virology·Zahra SalavatihaSomayeh Jalilvand
Jul 12, 2020·International Journal of Molecular Sciences·Amaia Vergara BermejoPeter Holst
Oct 30, 2020·International Journal of Molecular Sciences·Victoria GrögerHolger Cynis
Jun 1, 2021·Frontiers in Oncology·Eoin DervanSharon A Glynn

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Methods Mentioned

BETA
surgical resection
PCR
electrophoresis
histone acetylation

Software Mentioned

SPSS
RepeatMasker

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