Elevated high density lipoprotein cholesterol levels correlate with decreased apolipoprotein A-I and A-II fractional catabolic rate in women

The Journal of Clinical Investigation
E A BrintonJ L Breslow

Abstract

High levels of HDL-cholesterol (HDL-C) protect against coronary heart disease susceptibility, but the metabolic mechanisms underlying elevated HDL-C levels are poorly understood. We now report the turnover of isologous radioiodinated HDL apolipoproteins, apo A-I and apo A-II, in 15 female subjects on a metabolic diet with HDL-C levels ranging from 51 to 122 mg/dl. The metabolic parameters, fractional catabolic rate (FCR) and absolute synthetic rate (SR), were determined for apo A-I and apo A-II in all subjects. There was an inverse correlation between plasma HDL-C and the FCR of apo A-I and apo A-II (r = -0.75, P less than 0.001, and r = -0.54, P = 0.036, respectively), but no correlation with the SR of either apo A-I or apo A-II (r = 0.09, and r = -0.16, respectively, both P = NS). Apo A-I levels correlated inversely with apo A-I FCR (r = -0.64, P = 0.01) but not with apo A-I SR (r = 0.30, P = NS). In contrast, plasma levels of apo A-II did not correlate with apo A-II FCR (r = -0.38, P = 0.16), but did correlate with apo A-II SR (r = 0.65, P = 0.009). Further analysis showed that apo A-I and apo A-II FCR were inversely correlated with the HDL-C/apo A-I + A-II ratio (r = -0.69 and -0.61, P = 0.005 and 0.015, respectively). Thes...Continue Reading

References

Jun 1, 1976·Metabolism: Clinical and Experimental·J J AlbersJ J Hoover
Jul 1, 1977·The Journal of Clinical Investigation·M C Cheung, J J Albers
Sep 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·J R PatschS Eisenberg
May 1, 1985·The Journal of Clinical Investigation·K SakuM L Kashyap
Feb 1, 1985·The Journal of Clinical Investigation·E S KrulG Schonfeld
May 1, 1985·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·D Applebaum-BowdenW R Hazzard
May 1, 1982·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·K LiuD Moss
Aug 1, 1983·The Journal of Clinical Endocrinology and Metabolism·E J SchaeferR I Levy
Jul 15, 1983·Clinica Chimica Acta; International Journal of Clinical Chemistry·C L MalmendierJ P Ameryckx
Apr 1, 1983·Metabolism: Clinical and Experimental·S M HaffnerW R Hazzard
May 29, 1981·Biochemical and Biophysical Research Communications·K ShiraiR L Jackson
Jul 1, 1981·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·G FagerG Bondjers

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Citations

Feb 1, 1991·Clinical Cardiology·J T Gwynne
Jan 1, 1997·International Journal of Clinical & Laboratory Research·J E Hokanson
Nov 1, 2005·Current Atherosclerosis Reports·Patty W Siri, Ronald M Krauss
Sep 1, 1991·Atherosclerosis·M Seed
Jan 1, 1994·Pharmacology & Therapeutics·G FranceschiniL Calabresi
Jan 11, 1994·Biochimica Et Biophysica Acta·M N PietersT J Van Berkel
Mar 27, 2004·Metabolism: Clinical and Experimental·Marju Tilly-KiesiAlice H Lichtenstein
Mar 4, 2000·Clinica Chimica Acta; International Journal of Clinical Chemistry·J KobayashiY Saito
Mar 20, 2001·Atherosclerosis·P J PussinenM Jauhiainen
Feb 19, 2002·Atherosclerosis·Agnès PascotJean Pierre Després
Jul 18, 2002·Atherosclerosis·Anne TailleuxVéronique Clavey
Dec 1, 1990·Baillière's Clinical Endocrinology and Metabolism·M R Taskinen
Dec 1, 1990·Baillière's Clinical Endocrinology and Metabolism·D Crook, M Seed
Sep 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·R C Beavis, B T Chait
Jun 1, 1992·Journal of Internal Medicine·J L Breslow
Jun 1, 1992·Journal of Internal Medicine·A R Tall
Apr 1, 1994·The Journal of Clinical Investigation·N S ShachterJ L Breslow
Apr 1, 1997·The Journal of Clinical Investigation·L A Woollett, D K Spady
Sep 29, 1999·Proceedings of the National Academy of Sciences of the United States of America·Y Takahashi, J D Smith
Nov 18, 2006·Clinics in Laboratory Medicine·G Russell WarnickCleland C Landolt
Mar 24, 2016·Current Atherosclerosis Reports·C RosalesH J Pownall
May 1, 1997·Metabolism: Clinical and Experimental·L ElkhalilG Luc

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