Elevated high-sensitive troponin T on admission is an indicator of poor long-term outcome in patients with subarachnoid haemorrhage: a prospective observational study

Critical Care : the Official Journal of the Critical Care Forum
J OrasHelene Seeman-Lodding

Abstract

Patients with subarachnoid haemorrhage (SAH) frequently develop cardiac complications in the acute phase after the bleeding. Although a number of studies have shown that increased levels of cardiac biomarkers after SAH are associated with a worse short-term prognosis, no prospective, consecutive study has assessed the association between biomarker release and long-term outcome. We aimed to evaluate whether the cardiac biomarkers, high-sensitive troponin T (hsTnT) and N-terminal pro B-type natriuretic peptide (NTproBNP), were associated with poor 1-year neurological outcome and cerebral infarction due to delayed cerebral ischaemia (CI-DCI). In this single-centre prospective observational study, all consecutive patients admitted to our neurointensive care unit from January 2012 to December 2013 with suspected/verified SAH with an onset of symptoms <72 hours were enrolled. Blood samples for hsTnT and NTproBNP were collected during three consecutive days following admission. Patients were followed-up after 1 year using the Glasgow Outcome Scale Extended (GOSE). Poor neurological outcome was defined as GOSE ≤ 4. One hundred and seventy seven patients with suspected SAH were admitted during the study period; 143 fulfilled inclusion c...Continue Reading

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Citations

Aug 5, 2017·Circulation Research·Zhili ChenJieli Chen
May 18, 2018·European Journal of Preventive Cardiology·Annemarie AkkermansWilton A van Klei
Oct 7, 2017·Cardiology in Review·Ayman El-MenyarWilliam Frishman
Dec 5, 2020·Journal of the American College of Cardiology·Luciano A SposatoUNKNOWN World Stroke Organisation Brain & Heart Task Force

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