Elevated homocysteine levels in aqueous humor of patients with pseudoexfoliation glaucoma

American Journal of Ophthalmology
S BleichAnselm G M Jünemann

Abstract

To determine total homocysteine levels in aqueous humor of pseudoexfoliation open-angle glaucoma patients. Case-control study. Total homocysteine levels were measured by enzyme-linked immunosorbent assay in aqueous humor and plasma of 29 patients with pseudoexfoliation glaucoma and 31 control patients with cataract. Patients with factors affecting homocysteine levels were excluded. We observed significantly elevated (twofold) homocysteine levels in the aqueous humor of the glaucoma patients (Z = -5.11, P <.0001). Additionally, the calculated ratio (plasma:aqueous humor) was significantly lower in these patients (Z = -3.57, P <.001), and aqueous homocysteine was significantly correlated with their respective elevated plasma levels (r =.42, P =.02). Because homocysteine induces vascular injury and alterations of extracellular matrix, high aqueous homocysteine may trigger the abnormal matrix accumulation characteristic. It may reflect the proposed impairment of the blood-aqueous barrier of pseudoexfoliation open-angle glaucoma and be involved in its pathogenesis.

References

Oct 28, 1999·Journal of Cellular Biochemistry·C M Tummalapalli, S C Tyagi
Dec 18, 2002·Journal of Neural Transmission·S BleichJ Kornhuber
Feb 20, 2003·Trends in Neurosciences·Mark P Mattson, Thomas B Shea
Feb 26, 2003·Investigative Ophthalmology & Visual Science·Ursula Schlötzer-SchrehardtGottfried O H Naumann
Jul 2, 2003·American Journal of Ophthalmology·Roberto M VessaniMark Jofe

❮ Previous
Next ❯

Citations

Oct 12, 2012·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·A G M Jünemann
Oct 12, 2012·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·E Scharfenberg, U Schlötzer-Schrehardt
Feb 3, 2005·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Ozgül AltintaşYusuf Cağlar
Aug 27, 2010·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Laura TranchinaGianluca Manni
Aug 26, 2006·Journal of Neural Transmission·J B RoedlA G M Jünemann
Jan 24, 2007·Journal of Neural Transmission·J B RoedlA G M Jünemann
Nov 8, 2012·Cornea·Berrak SekeryapanMustafa Durmus
Nov 6, 2009·The Open Ophthalmology Journal·Allison Angelilli, Robert Ritch
Feb 10, 2010·Middle East African Journal of Ophthalmology·Allison Angelilli, Robert Ritch
Feb 7, 2013·Oman Medical Journal·Rana SorkhabiNadereh Rashtchizadeh
Oct 2, 2013·North American Journal of Medical Sciences·Vasiliki KatsiIoannis Kallikazaros
Jun 15, 2007·Ophthalmic Genetics·Madeleine ZetterbergHenrik Zetterberg
Mar 31, 2012·Current Eye Research·Asaad A GhanemLamiaa F Arafa
Sep 24, 2008·Experimental Eye Research·Ursula Schlötzer-Schrehardt
Dec 10, 2015·Acta Ophthalmologica·Louis R PasqualeRobert Ritch
May 9, 2006·American Journal of Ophthalmology·Ursula Schlötzer-Schrehardt, Gottfried O H Naumann
Apr 6, 2005·American Journal of Ophthalmology·Anselm G M JünemannStefan Bleich
May 15, 2013·Seminars in Ophthalmology·Tongabay CumurcuErcan Ozsoy
Jan 14, 2017·Current Eye Research·Mehmet TetikoğluÖzcan Erel
Mar 17, 2017·International Ophthalmology·Prakadeeswari GopalakrishnanPeriasamy Sundaresan
Feb 10, 2018·Ophthalmology and Therapy·Adi M Al Owaifeer, Abdulaziz A Al Taisan
May 3, 2007·Journal of Glaucoma·Johannes B RoedlAnselm G Jünemann
Aug 1, 2007·Proteomics. Clinical Applications·Franz H GrusNorbert Pfeiffer
Dec 18, 2008·Acta Ophthalmologica·Ahti Tarkkanen
Jan 15, 2009·Journal of Glaucoma·Colin I ClementStuart L Graham
Feb 25, 2010·Journal of Glaucoma·Christopher W RösslerAnselm G M Juenemann
Apr 27, 2007·Annals of the New York Academy of Sciences·Zuhal YildirimAylin Sepici-Dinçel
Jul 8, 2011·Journal of Glaucoma·Peter A ZakrzewskiFrederick S Mikelberg
Aug 30, 2014·International Ophthalmology Clinics·Daniel I BettisBarbara M Wirostko
Aug 30, 2014·International Ophthalmology Clinics·Louis R PasqualeJaney L Wiggs
Aug 30, 2014·International Ophthalmology Clinics·Mohammed Khalil, Robert Ritch
Oct 3, 2014·Journal of Glaucoma·Robert Ritch
Sep 30, 2014·Journal of Glaucoma·Mehmet A SekerogluMehmet Orhan
Jan 17, 2015·Current Opinion in Ophthalmology·Samantha Dewundara, Louis R Pasquale
Oct 9, 2015·Eye & Contact Lens·Serpil YazganMehmet Orcun Akdemir
Mar 10, 2020·Molecular Omics·Ciara MyerSanjoy K Bhattacharya
Jul 3, 2018·Journal of Glaucoma·Khalid KamelColm O'Brien
Feb 18, 2016·Asia-Pacific Journal of Ophthalmology·Robert Ritch
Feb 20, 2020·Experimental Eye Research·Alison G GreeneDeborah M Wallace
Jun 1, 2021·Frontiers in Molecular Biosciences·Diana Anna DmuchowskaMichal Ciborowski
Jun 26, 2021·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Tzukit Zehavi-DorinHani Levkovitch-Verbin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Glaucoma
Igal LeibovitchAnat Loewenstein
Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie
Tuomo PuustjärviM E Teräsvirta
© 2022 Meta ULC. All rights reserved