Elevated IgG Responses in Infants Are Associated With Reduced Prevalence of Mycobacterium tuberculosis Infection

Frontiers in Immunology
Erin LoganMark Hatherill

Abstract

It is unclear whether antibodies can prevent Mycobacterium tuberculosis (Mtb) infection. In this study, we examined the relationship between total plasma IgG levels, IgG elicited by childhood vaccines and soil-transmitted helminths, and Mtb infection prevalence, defined by positive QuantiFERON (QFT) test. We studied 100 Mtb uninfected infants, aged 4-6 months. Ten infants (10%) converted to positive QFT test (QFT+) within 2 years of follow-up for Mtb infection. Antibody responses in plasma samples acquired at baseline and tuberculosis investigation were analyzed by enzyme-linked immunosorbent assay and ImmunoCAP® assay. QFT- infants displayed a significant increase in total IgG titers when re-tested, compared to IgG titers at baseline, which was not observed in QFT+ infants. Bacille Calmette-Guérin (BCG) vaccine-specific IgG2 and live-attenuated measles vaccine-specific IgG were raised in QFT- infants, and infants who acquired an Mtb infection did not appear to launch a BCG-specific IgG2 response. IgG titers against the endemic helminth Ascaris lumbricoides increased from baseline to QFT re-testing in all infants. These data show raised IgG associates with a QFT-status. Importantly, this effect was also associated with a trend ...Continue Reading

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Citations

Jan 15, 2020·The Journal of Clinical Investigation·Tingting ChenJacqueline M Achkar
May 30, 2019·Immunology and Cell Biology·Pia SteiglerJoanna R Kirman
May 13, 2020·Parasite Immunology·Gillian CoakleyNicola Laraine Harris
Mar 9, 2021·Frontiers in Immunology·Willemijn F RijninkSimone A Joosten

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Methods Mentioned

BETA
glycosylation
enzyme-linked immunosorbent assay
ELISA
ELISAs

Software Mentioned

GraphPad Prism

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