Elevated immunoglobulin G4 level is associated with reduced colectomy-free survival in patients with primary sclerosing cholangitis and ulcerative colitis

Journal of Crohn's & Colitis
Udayakumar NavaneethanRavi P Kiran

Abstract

Patients with primary sclerosing cholangitis (PSC) and elevated immunoglobulin (Ig) G4 have been shown to have more severe disease with a shorter time to orthotopic liver transplantation (OLT). The aim of the study was to investigate the clinical outcomes of PSC and UC in patients with elevated serum IgG4. We analyzed data from 50 patients with PSC and known serum levels of IgG4. They were divided into groups called high IgG4 (>112 IU/L; n = 10) or normal IgG4 (n = 40). We compared the requirement of OLT and colectomy between groups. High IgG4 was found in 10 PSC patients (20%). UC was associated in 9/10 patients with high IgG4 vs. 32/40 patients with normal IgG4 (p=0.67). Patients with high IgG4 were younger at PSC diagnosis (28.1 ± 13.9 vs. 37.6 ± 13.4 years, P=0.04), more likely to have backwash ileitis (7/9 vs. 12/32, P < 0.001) and UC flares (median of 5.5 vs. 1.5, P = 0.02). Kaplan-Meier curve analysis showed that patients with elevated IgG4 had reduced colectomy-free survival than patients with normal IgG4 (Log Rank p < 0.001). The median time to colectomy was 5 years from UC diagnosis in high IgG4 group vs. 12 years in the normal IgG4 group (p = 0.01). Elevated IgG4 was seen in a small number of PSC patients. Most of th...Continue Reading

References

Mar 1, 1992·Current Problems in Surgery·F M Martin, J W Braasch
Feb 1, 1991·Seminars in Liver Disease·O FausaK Elgjo
May 29, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·W R KimE R Dickson
Oct 11, 2001·Journal of Pediatric Gastroenterology and Nutrition·W A FaubionJ Perrault
Dec 1, 1963·American Journal of Clinical Pathology·S L SALTZSTEIN, B F ROSENBERG
Feb 6, 2004·Gastroenterology·Matthew RutterAlastair Forbes
Jun 30, 2005·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Masahiro MatsushitaYoshimasa Kobayashi
Feb 24, 2006·Seminars in Liver Disease·Ulrika Broomé, Annika Bergquist
Aug 2, 2006·The American Journal of Gastroenterology·Flavia D MendesKeith D Lindor
Mar 20, 2009·The American Journal of Surgical Pathology·Mee JooRobert Daniel Odze
Dec 26, 2009·The American Journal of Surgical Pathology·Lizhi ZhangTsung-Teh Wu
Mar 4, 2010·Inflammatory Bowel Diseases·Udayakumar Navaneethan, Bo Shen
Jul 5, 2011·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Udayakumar NavaneethanBo Shen
Jul 27, 2011·Biochemical Society Transactions·Paul FlanaganJonathan M Rhodes
Aug 3, 2011·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Andrea V ArrossiJohn R Goldblum
Sep 24, 2011·Journal of Crohn's & Colitis·Udayakumar NavaneethanBo Shen
Nov 26, 2011·Journal of Crohn's & Colitis·Udayakumar NavaneethanBo Shen
Jan 1, 1997·Inflammatory Bowel Diseases·E V LoftusN F Larusso

❮ Previous
Next ❯

Citations

Jul 31, 2013·Journal of Autoimmunity·Palak J Trivedi, David H Adams
Apr 23, 2014·International Journal of Experimental Pathology·Sandra FischerGideon M Hirschfield
Dec 2, 2014·Inflammatory Bowel Diseases·Darren N SerilBo Shen
Jun 29, 2016·Medical Molecular Morphology·Hiep Nguyen Canh, Kenichi Harada
Jan 1, 2014·Inflammatory Bowel Diseases·Darren N SerilBo Shen
Jun 22, 2014·Gastroenterology Report·Udayakumar Navaneethan
Jul 21, 2020·World Journal of Gastroenterology : WJG·Charis D ManganisEmma L Culver
Jul 31, 2021·Liver International : Official Journal of the International Association for the Study of the Liver·Taotao ZhouTobias J Weismüller

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aphasia

Aphasia affects the ability to process language, including formulation and comprehension of language and speech, as well as the ability to read or write. Here is the latest research on aphasia.