Elevated interleukin 31 serum levels in hemodialysis patients are associated with uremic pruritus.

Cytokine
Ashraf O OweisSameeha A Alshelleh

Abstract

Uremic pruritus is a multifactorial devastating complication of renal failure, which has a significant negative impact on patients' quality of life including medical, psychological, as well as social aspects. It is also associated with an increased mortality in dialysis patients. A cross sectional study evaluating the traditional risk factors for uremic pruritus (UP) - using pruritus grading system (PGS) and visual analogue scale (VAS) - as well as measuring the serum levels of different inflammatory cytokines (ILs 13, 31 and 33) in chronic hemodialysis and healthy controls, in a tertiary referral hospital. 65 hemodialysis (HD) patients and 49 heathy controls were enrolled in the study. The mean age for the HD patients was 43.4 years (SD ± 21.3), and 31.5 years (SD ± 11.1) for the control group. The most common cause for End Stage Renal Disease (ESRD) was diabetes mellitus (DM) 27.7%. The mean PGS score in HD patients was 5.92 (SD ± 2.9); 50% had mild itch, 43.8% moderate itch and 6.2% had severe itch. The mean serum levels for IL-13 was 8674.3 pg/ml (SD ± 4353.9), serum levels of IL-31 were 150.7 pg/ml (SD ± 178.2) and for IL-33 it was 42850.5 pg/ml (SD ± 11370.7) in hemodialysis patients; in comparison to serum levels of 7913...Continue Reading

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Citations

Mar 2, 2021·Frontiers in Medicine·Kenji Kabashima, Hiroyuki Irie
May 1, 2021·Journal of Clinical Medicine·Masutaka Furue, Mihoko Furue
May 26, 2021·Experimental Dermatology·Giuseppe IngrasciGil Yosipovitch
Jul 3, 2021·Toxins·Radomir ReszkeJacek C Szepietowski
Jul 21, 2021·International Journal of Molecular Sciences·Lai-San WongChih-Hung Lee
Aug 27, 2021·Toxins·Puneet AgarwalMohamad Goldust
Sep 24, 2021·Biomarkers in Medicine·Hussein K Al-HakeimMichael Maes

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