Elevated interleukin-6 levels in cerebrospinal fluid of vascular dementia patients

Acta Neurologica Scandinavica
K Wada-IsoeK Nakashima

Abstract

To investigate a possible implication of inflammatory processes in the development of dementia in cerebrovascular disease. We examined the levels of interleukin-6 (IL-6) in the cerebrospinal fluid (CSF) of patients with Alzheimer's disease (AD) (n = 26), ischemic cerebrovascular disease without dementia (CVD) (n = 11), vascular dementia (VD) (n = 11), and other neurological disorders (n = 21) using sensitive enzyme-linked immunosorbent assay. The CSF concentrations of IL-6 were significantly elevated in patients with VD compared with those of patients with AD or CVD. The CSF IL-6 levels are increased in patients with VD, suggesting that inflammatory mechanisms may be involved in the development of cognitive decline in some patients with cerebrovascular disease. CSF IL-6 may be a biological marker for dementia in cerebrovascular disease.

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Citations

Sep 18, 2009·Journal of Neurology·Kurt A Jellinger
Nov 13, 2004·Journal of Clinical Psychopharmacology·Theoharis C TheoharidesPio Conti
Feb 28, 2008·Dementia and Geriatric Cognitive Disorders·Ezra MulugetaPaul T Francis
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Jan 18, 2019·Psychiatry and Clinical Neurosciences·Hiroaki Hori, Yoshiharu Kim
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Feb 19, 2021·Scientific Reports·Yuek Ling ChaiMitchell K P Lai

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