PMID: 6402407Mar 1, 1983Paper

Elevated intestinal disaccharidase activity in the streptozotocin-diabetic rat is independent of enteral feeding

Diabetes
H P SchedlH D Wilson

Abstract

Specific and total activities of the disaccharidases, sucrase, maltase, and lactase are increased in mucosa of the small intestine of the streptozotocin diabetic rat. Because disaccharidases are essential for terminal digestion of carbohydrate, and disaccharidase deficiency is a common clinical problem, understanding the mechanisms regulating disaccharidase activity is important. In normal animals, disaccharidase activities are determined by route of feeding and are decreased by parenteral feeding. The indirect exocrine, endocrine, neurocrine, and paracrine functions of the gastrointestinal tract that are dependent on feeding via the gut are greatly decreased in parenteral as compared with enteral feeding. Hormone secretion by the gut and the pattern of response after feeding may be abnormal in diabetes and might be regulatory for disaccharidases. We tested the hypothesis that the elevated intestinal disaccharidases in diabetes are dependent on enteral feeding. Streptozotocin-injected rats (diabetics) and vehicle-injected rats (controls) were fed rat chow ad libitum for 4 days. A subset of control and diabetic animals was then killed to determine disaccharidase activity of the jejunum at the start of pair-feeding the elemental ...Continue Reading

Citations

Jan 1, 1985·Comparative Biochemistry and Physiology. A, Comparative Physiology·M KeelanA B Thomson
Mar 4, 2005·Molecular Nutrition & Food Research·Rashmi RamachandraParamahans V Salimath
Jul 12, 2005·Molecular Nutrition & Food Research·Ajaya Kumar ShettyParamahans Veerayya Salimath
Apr 29, 2010·Molecular Nutrition & Food Research·Kazuki MochizukiToshinao Goda
Nov 26, 1998·Scandinavian Journal of Gastroenterology·I Murakami, T Ikeda
Mar 10, 2001·The American Journal of Clinical Nutrition·G F MeloniT Meloni

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