Elevated lactate dehydrogenase activity and increased cardiovascular mortality in the arsenic-endemic areas of southwestern Taiwan

Toxicology and Applied Pharmacology
Ya-Tang LiaoShu-Li Wang

Abstract

Arsenic ingestion has been linked to increasing global prevalence of and mortality from cardiovascular disease (CVD); arsenic can be removed from drinking water to reduce related health effects. Lactate dehydrogenase (LDH) is used for the evaluation of acute arsenic toxicity in vivo and in vitro, but it is not validated for the evaluation of long-term, chronic arsenic exposure. The present study examined the long-term effect of chronic arsenic exposure on CVD and serum LDH levels, after consideration of arsenic metabolism capacity. A total of 380 subjects from an arseniasis-endemic area and 303 from a non-endemic area of southwestern Taiwan were recruited in 2002. Various urinary arsenic species were analyzed using high-performance liquid chromatography (HPLC) and hydride generation systems. Fasting serum was used for quantitative determination of the total LDH activity. A significant dose-response relationship was observed between arsenic exposure and LDH elevation, independent of urinary arsenic profiles (P<0.001). Furthermore, abnormal LDH elevation was associated with CVD mortality after adjustment for Framingham risk scores for 10-year CVD and arsenic exposure (hazard ratio, 3.98; 95% confidence interval, 1.07-14.81). LDH ...Continue Reading

References

Apr 14, 1975·JAMA : the Journal of the American Medical Association·R S GalenR Gambino
Jul 1, 1992·Environmental Health Perspectives·A H SmithM T Smith
Jun 1, 1996·Environmental Health Perspectives·C Hopenhayn-RichL E Moore
Jul 14, 1998·Journal of Toxicology and Environmental Health. Part a·Y M HsuehC J Chen
Sep 25, 2002·Toxicology Letters·Paritosh C PaulM A Mannan
Jul 12, 2003·Environmental Research·Christopher A LoffredoEllen K Silbergeld
Jun 22, 2005·Toxicology and Applied Pharmacology·D N Guha Mazumder
Nov 5, 2005·American Journal of Epidemiology·Ana Navas-AcienEliseo Guallar
Apr 7, 2006·The Journal of Pharmacy and Pharmacology·Sherif Y SaadMaha M Arafah
Jan 22, 2008·Clinics in Sports Medicine·Paola BrancaccioFrancesco Mario Limongelli
Jan 24, 2008·Circulation·Ralph B D'AgostinoWilliam B Kannel
Aug 21, 2008·JAMA : the Journal of the American Medical Association·Ana Navas-AcienEliseo Guallar
Sep 5, 2009·Epidemiology·Matthew P Longnecker
Nov 3, 2010·The Science of the Total Environment·Md Rezaul KarimKhaled Hossain

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Citations

Sep 23, 2014·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Ranjan Kumar MohantaRam Sharan Dass
Sep 13, 2012·Current Atherosclerosis Reports·Katherine MoonAna Navas-Acien
Dec 21, 2014·The American Journal of Clinical Nutrition·Isao MurakiQi Sun
Oct 19, 2017·International Journal of Epidemiology·Katherine A MoonAna Navas-Acien

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